Back to trial
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity
is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip
the pipeline's suppression passes); the authoritative classification is the stored
event record.
Plain-language summary
Manual review pending.
Rules fired
arms_or_interventions_change
Value signals
None recorded.
Provenance
Source ctgov_internal_history
Fetched 2026-06-18 18:57:42+00
Raw hash 94109c16cf384f046c03b3d9b5d08960724bfe0d6d85e84c26df1683dd30eed9 Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 4 ops add /protocolSection/armsInterventionsModule/armGroups/5
Triage: High Arm Intervention Change Operation 8
Matched rules arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure. After
{
"type": "EXPERIMENTAL",
"label": "Dose Expansion Recurrent Glioblastoma",
"description": "Recurrent GBM patients must have completed radiation at least 3 months prior to minimize the inclusion of patients with pseudoprogression.\nRecurrent GBM patients must have unequivocal radiographic evidence of tumor progression by contrast-enhanced magnetic resonance imaging (MRI) scan within 21 days prior to registration.\nPatients must be able to delay surgery for 2 - 4 weeks per investigator decision",
"interventionNames": [
"Drug: ST101"
]
} add /protocolSection/armsInterventionsModule/armGroups/6
Triage: High Arm Intervention Change Operation 9
Matched rules arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure. After
{
"type": "EXPERIMENTAL",
"label": "Newly Diagnosed Glioblastoma",
"description": "Newly diagnosed patients with a suboptimal resection or biopsy must be candidates for another surgical resection as determined by neurosurgical evaluation or multidisciplinary team based on the current standard of care that suggests that maximal safe resection is beneficial.\nRecurrent GBM patients must be candidates for tumor resection",
"interventionNames": [
"Drug: ST101"
]
} add /protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/5
Triage: High Arm Intervention Change Operation 10
Matched rules arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure. After
Dose Expansion Recurrent Glioblastoma add /protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/6
Triage: High Arm Intervention Change Operation 11
Matched rules arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure. After
Newly Diagnosed Glioblastoma Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 1 ops replace /protocolSection/contactsLocationsModule/overallOfficials/1/name
Triage: Uncategorized Uncategorized Operation 12
After
Abi Vainstein-Haras, MD Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 7 ops replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized Uncategorized Operation 1
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized Uncategorized Operation 2
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized Uncategorized Operation 3
remove /protocolSection/conditionsModule/conditions/2
Triage: Uncategorized Uncategorized Operation 4
Before
Melanoma Recurrent add /protocolSection/conditionsModule/conditions/10
Triage: Uncategorized Uncategorized Operation 5
add /protocolSection/conditionsModule/conditions/12
Triage: Uncategorized Uncategorized Operation 6
After
Recurrent Glioblastoma add /protocolSection/conditionsModule/conditions/13
Triage: Uncategorized Uncategorized Operation 7
After
Newly Diagnosed Glioblastoma Raw JSON Patch [
{
"op": "replace",
"path": "/protocolSection/statusModule/statusVerifiedDate",
"value": "2023-02"
},
{
"op": "replace",
"path": "/protocolSection/statusModule/lastUpdateSubmitDate",
"value": "2023-02-14"
},
{
"op": "replace",
"path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
"value": "2023-02-16"
},
{
"op": "remove",
"path": "/protocolSection/conditionsModule/conditions/2"
},
{
"op": "add",
"path": "/protocolSection/conditionsModule/conditions/10",
"value": "Melanoma Recurrent"
},
{
"op": "add",
"path": "/protocolSection/conditionsModule/conditions/12",
"value": "Recurrent Glioblastoma"
},
{
"op": "add",
"path": "/protocolSection/conditionsModule/conditions/13",
"value": "Newly Diagnosed Glioblastoma"
},
{
"op": "add",
"path": "/protocolSection/armsInterventionsModule/armGroups/5",
"value": {
"type": "EXPERIMENTAL",
"label": "Dose Expansion Recurrent Glioblastoma",
"description": "Recurrent GBM patients must have completed radiation at least 3 months prior to minimize the inclusion of patients with pseudoprogression.\nRecurrent GBM patients must have unequivocal radiographic evidence of tumor progression by contrast-enhanced magnetic resonance imaging (MRI) scan within 21 days prior to registration.\nPatients must be able to delay surgery for 2 - 4 weeks per investigator decision",
"interventionNames": [
"Drug: ST101"
]
}
},
{
"op": "add",
"path": "/protocolSection/armsInterventionsModule/armGroups/6",
"value": {
"type": "EXPERIMENTAL",
"label": "Newly Diagnosed Glioblastoma",
"description": "Newly diagnosed patients with a suboptimal resection or biopsy must be candidates for another surgical resection as determined by neurosurgical evaluation or multidisciplinary team based on the current standard of care that suggests that maximal safe resection is beneficial.\nRecurrent GBM patients must be candidates for tumor resection",
"interventionNames": [
"Drug: ST101"
]
}
},
{
"op": "add",
"path": "/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/5",
"value": "Dose Expansion Recurrent Glioblastoma"
},
{
"op": "add",
"path": "/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/6",
"value": "Newly Diagnosed Glioblastoma"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/overallOfficials/1/name",
"value": "Abi Vainstein-Haras, MD"
}
]