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NCT04478279

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Version 14 to 15 · Sapience Therapeutics

Patch inspector

Version 14 to 15

9 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:57:42+00
Raw hash
1a1178bfad272b220595c1c0ef0532c6f94ce750a485d8aaa73aacfed081127b
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 4 ops
add /protocolSection/armsInterventionsModule/armGroups/6/interventionNames/1
Triage: High
Arm Intervention Change Operation 4
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Temozolomide
add /protocolSection/armsInterventionsModule/armGroups/6/interventionNames/2
Triage: High
Arm Intervention Change Operation 5
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Radiation: Radiation
add /protocolSection/armsInterventionsModule/interventions/1
Triage: High
Arm Intervention Change Operation 6
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
{
  "name": "Temozolomide",
  "type": "DRUG",
  "description": "Temozolomide",
  "armGroupLabels": [
    "Newly Diagnosed Glioblastoma"
  ]
}
add /protocolSection/armsInterventionsModule/interventions/2
Triage: High
Arm Intervention Change Operation 7
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
{
  "name": "Radiation",
  "type": "RADIATION",
  "description": "Radiation",
  "armGroupLabels": [
    "Newly Diagnosed Glioblastoma"
  ]
}
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 2 ops
replace /protocolSection/contactsLocationsModule/locations/7/status
Triage: Uncategorized
Uncategorized Operation 8
Before
RECRUITING
After
WITHDRAWN
remove /protocolSection/contactsLocationsModule/locations/7/contacts
Triage: Uncategorized
Uncategorized Operation 9
Before
[
  {
    "name": "Julie Morehouse",
    "role": "CONTACT",
    "email": "Julie.morehouse@usoncology.com",
    "phone": "214-370-1238"
  },
  {
    "name": "Joyce O'Shaughnessy, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2023-02
After
2023-05
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2023-02-14
After
2023-05-10
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2023-02-16
After
2023-05-12
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2023-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2023-05-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2023-05-12"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/6/interventionNames/1",
    "value": "Drug: Temozolomide"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/6/interventionNames/2",
    "value": "Radiation: Radiation"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/1",
    "value": {
      "name": "Temozolomide",
      "type": "DRUG",
      "description": "Temozolomide",
      "armGroupLabels": [
        "Newly Diagnosed Glioblastoma"
      ]
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/2",
    "value": {
      "name": "Radiation",
      "type": "RADIATION",
      "description": "Radiation",
      "armGroupLabels": [
        "Newly Diagnosed Glioblastoma"
      ]
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/status",
    "value": "WITHDRAWN"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/7/contacts"
  }
]