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NCT04478279

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Version 19 to 20 · Sapience Therapeutics

Patch inspector

Version 19 to 20

44 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_changeenrollment_count_changeenrollment_type_change
Value signals
[
  {
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "signal": "enrollment_count_change_ge_20pct",
    "category": "enrollment_change",
    "severity": "high",
    "new_value": 125,
    "old_value": 162,
    "pct_change": 0.2284
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:57:43+00
Raw hash
84087a642f40b5740e9790cb748ca3168897ad23a687e3a40a39085f60b9d32d
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 2 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 5
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
162
After
125
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 6
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 38 ops
remove /protocolSection/contactsLocationsModule/centralContacts
Triage: Low
Administrative Contact Change Operation 7
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
[
  {
    "name": "Steve Kaesshaefer",
    "role": "CONTACT",
    "email": "steve.kaesshaefer@bexonclinical.com",
    "phone": "+1 973-715-2917"
  }
]
remove /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 8
Before
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1/status
Triage: Uncategorized
Uncategorized Operation 9
Before
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/2/status
Triage: Uncategorized
Uncategorized Operation 10
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/2/contacts
Triage: Uncategorized
Uncategorized Operation 11
Before
[
  {
    "name": "Neuro Oncology Research Coordinator",
    "role": "CONTACT",
    "email": "anastasia.papaioannou@nm.org",
    "phone": "630-938-2085"
  },
  {
    "name": "Vinai Gondi, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
remove /protocolSection/contactsLocationsModule/locations/3/status
Triage: Uncategorized
Uncategorized Operation 12
Before
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/4/status
Triage: Uncategorized
Uncategorized Operation 13
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/4/contacts
Triage: Uncategorized
Uncategorized Operation 14
Before
[
  {
    "name": "Alyssa Schumpp",
    "role": "CONTACT",
    "email": "as6498@cumc.columbia.edu",
    "phone": "212-342-0139"
  },
  {
    "name": "Fabio Iwamoto, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
remove /protocolSection/contactsLocationsModule/locations/5/status
Triage: Uncategorized
Uncategorized Operation 15
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/5/contacts
Triage: Uncategorized
Uncategorized Operation 16
Before
[
  {
    "name": "Katy Peters, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
remove /protocolSection/contactsLocationsModule/locations/6/status
Triage: Uncategorized
Uncategorized Operation 17
Before
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/7/facility
Triage: Uncategorized
Uncategorized Operation 18
Before
Texas Oncology - Baylor Charles A. Sammons Cancer Center
After
Edinburgh Cancer Centre
remove /protocolSection/contactsLocationsModule/locations/7/status
Triage: Uncategorized
Uncategorized Operation 19
Before
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/7/city
Triage: Uncategorized
Uncategorized Operation 20
Before
Dallas
After
Edinburgh
remove /protocolSection/contactsLocationsModule/locations/7/state
Triage: Uncategorized
Uncategorized Operation 21
Before
Texas
replace /protocolSection/contactsLocationsModule/locations/7/zip
Triage: Uncategorized
Uncategorized Operation 22
Before
75246
After
EH4 2SP
replace /protocolSection/contactsLocationsModule/locations/7/country
Triage: Uncategorized
Uncategorized Operation 23
Before
United States
After
United Kingdom
replace /protocolSection/contactsLocationsModule/locations/7/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 24
Before
32.78306
After
55.95206
replace /protocolSection/contactsLocationsModule/locations/7/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 25
Before
-96.80667
After
-3.19648
replace /protocolSection/contactsLocationsModule/locations/8/facility
Triage: Uncategorized
Uncategorized Operation 26
Before
Edinburgh Cancer Centre
After
The Beaston West of Scotland Cancer Centre
remove /protocolSection/contactsLocationsModule/locations/8/status
Triage: Uncategorized
Uncategorized Operation 27
Before
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/8/city
Triage: Uncategorized
Uncategorized Operation 28
Before
Edinburgh
After
Glasgow
replace /protocolSection/contactsLocationsModule/locations/8/zip
Triage: Uncategorized
Uncategorized Operation 29
Before
EH4 2SP
After
G12 0YN
replace /protocolSection/contactsLocationsModule/locations/8/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 30
Before
55.95206
After
55.86515
replace /protocolSection/contactsLocationsModule/locations/8/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 31
Before
-3.19648
After
-4.25763
replace /protocolSection/contactsLocationsModule/locations/9/facility
Triage: Uncategorized
Uncategorized Operation 32
Before
The Beaston West of Scotland Cancer Centre
After
University of Leeds
remove /protocolSection/contactsLocationsModule/locations/9/status
Triage: Uncategorized
Uncategorized Operation 33
Before
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/9/city
Triage: Uncategorized
Uncategorized Operation 34
Before
Glasgow
After
Leeds
replace /protocolSection/contactsLocationsModule/locations/9/zip
Triage: Uncategorized
Uncategorized Operation 35
Before
G12 0YN
After
LS9 7TF
replace /protocolSection/contactsLocationsModule/locations/9/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 36
Before
55.86515
After
53.79648
replace /protocolSection/contactsLocationsModule/locations/9/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 37
Before
-4.25763
After
-1.54785
replace /protocolSection/contactsLocationsModule/locations/10/facility
Triage: Uncategorized
Uncategorized Operation 38
Before
University of Leeds
After
Sarah Cannon Research Institute UK
remove /protocolSection/contactsLocationsModule/locations/10/status
Triage: Uncategorized
Uncategorized Operation 39
Before
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/10/city
Triage: Uncategorized
Uncategorized Operation 40
Before
Leeds
After
London
replace /protocolSection/contactsLocationsModule/locations/10/zip
Triage: Uncategorized
Uncategorized Operation 41
Before
LS9 7TF
After
W1G 6AD
replace /protocolSection/contactsLocationsModule/locations/10/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 42
Before
53.79648
After
51.50853
replace /protocolSection/contactsLocationsModule/locations/10/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 43
Before
-1.54785
After
-0.12574
remove /protocolSection/contactsLocationsModule/locations/11
Triage: Uncategorized
Uncategorized Operation 44
Before
{
  "zip": "W1G 6AD",
  "city": "London",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United Kingdom",
  "facility": "Sarah Cannon Research Institute UK",
  "geoPoint": {
    "lat": 51.50853,
    "lon": -0.12574
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2024-02
After
2024-08
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2024-02-28
After
2024-08-08
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2024-03-01
After
2024-08-09
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2024-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2024-08-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2024-08-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 125
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/centralContacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/2/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/2/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/3/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/5/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/5/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/facility",
    "value": "Edinburgh Cancer Centre"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/7/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/city",
    "value": "Edinburgh"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/7/state"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/zip",
    "value": "EH4 2SP"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/country",
    "value": "United Kingdom"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/geoPoint/lat",
    "value": 55.95206
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/geoPoint/lon",
    "value": -3.19648
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/8/facility",
    "value": "The Beaston West of Scotland Cancer Centre"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/8/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/8/city",
    "value": "Glasgow"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/8/zip",
    "value": "G12 0YN"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/8/geoPoint/lat",
    "value": 55.86515
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/8/geoPoint/lon",
    "value": -4.25763
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/facility",
    "value": "University of Leeds"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/9/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/city",
    "value": "Leeds"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/zip",
    "value": "LS9 7TF"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/geoPoint/lat",
    "value": 53.79648
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/geoPoint/lon",
    "value": -1.54785
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/facility",
    "value": "Sarah Cannon Research Institute UK"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/10/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/city",
    "value": "London"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/zip",
    "value": "W1G 6AD"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/geoPoint/lat",
    "value": 51.50853
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/geoPoint/lon",
    "value": -0.12574
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/11"
  }
]