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NCT04578106

Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy

Version 2 to 3 · Fundacio Clinic Barcelona

Patch inspector

Version 2 to 3

5 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2026-12",
    "old_value": "2023-12",
    "delta_days": 1096,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:14:25+00
Raw hash
e6263ad6b439fd0bd88ac9e8303399b931291e97569717527595ee5a3398be31
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2023-12
After
2026-12
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2022-01
After
2024-05
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2022-01-23
After
2024-05-11
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2022-01-25
After
2024-05-14
add /annotationSection
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "annotationModule": {
    "unpostedAnnotation": {
      "unpostedEvents": [
        {
          "date": "2025-09-05",
          "type": "RELEASE"
        },
        {
          "date": "2025-09-26",
          "type": "RESET"
        },
        {
          "date": "2025-12-10",
          "type": "RELEASE"
        },
        {
          "date": "2025-12-30",
          "type": "RESET"
        }
      ],
      "unpostedResponsibleParty": "Fundacio Clinic Barcelona"
    }
  }
}
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2024-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2026-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2024-05-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2024-05-14"
  },
  {
    "op": "add",
    "path": "/annotationSection",
    "value": {
      "annotationModule": {
        "unpostedAnnotation": {
          "unpostedEvents": [
            {
              "date": "2025-09-05",
              "type": "RELEASE"
            },
            {
              "date": "2025-09-26",
              "type": "RESET"
            },
            {
              "date": "2025-12-10",
              "type": "RELEASE"
            },
            {
              "date": "2025-12-30",
              "type": "RESET"
            }
          ],
          "unpostedResponsibleParty": "Fundacio Clinic Barcelona"
        }
      }
    }
  }
]