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NCT04584853

PreOperative Endocrine Therapy for Individualised Care With Abemaciclib

Version 0 to 1 · Institute of Cancer Research, United Kingdom

Patch inspector

Version 0 to 1

24 operations 5 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2020-12-23",
    "old_value": "2020-11-01",
    "delta_days": 52,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:44:33+00
Raw hash
fbe24eed83defd3bf2cdf5e39873b9c918574fe9e6364ae983735612156a5be1
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2020-11-01
After
2020-12-23
replace /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 16 ops
replace /protocolSection/contactsLocationsModule/locations/0/facility
Triage: Uncategorized
Uncategorized Operation 9
Before
Royal Marsden NHS Foundation Trust
After
Queen Elizabeth Hospital
replace /protocolSection/contactsLocationsModule/locations/0/city
Triage: Uncategorized
Uncategorized Operation 10
Before
London
After
Kings Lynn
replace /protocolSection/contactsLocationsModule/locations/0/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 11
Before
51.50853
After
52.75172
replace /protocolSection/contactsLocationsModule/locations/0/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 12
Before
-0.12574
After
0.39516
add /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 13
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/0/state
Triage: Uncategorized
Uncategorized Operation 14
After
England
add /protocolSection/contactsLocationsModule/locations/0/zip
Triage: Uncategorized
Uncategorized Operation 15
After
PE30 4ET
add /protocolSection/contactsLocationsModule/locations/0/contacts
Triage: Uncategorized
Uncategorized Operation 16
After
[
  {
    "name": "Nicola Ainsworth, MD",
    "role": "CONTACT"
  }
]
add /protocolSection/contactsLocationsModule/locations/1
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "SN3 6BB",
  "city": "Swindon",
  "state": "England",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Anne Kendal, MD",
      "role": "CONTACT"
    }
  ],
  "facility": "Great Western Hospital",
  "geoPoint": {
    "lat": 51.55797,
    "lon": -1.78116
  }
}
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 18
After
{
  "city": "Aberdeen",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Ravi Sharma, MD",
      "role": "CONTACT"
    }
  ],
  "facility": "Aberdeen Royal Infirmary",
  "geoPoint": {
    "lat": 57.14369,
    "lon": -2.09814
  }
}
add /protocolSection/contactsLocationsModule/locations/3
Triage: Uncategorized
Uncategorized Operation 19
After
{
  "city": "Bournemouth",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Anthony Skene",
      "role": "CONTACT"
    }
  ],
  "facility": "Royal Bournemouth Hospital",
  "geoPoint": {
    "lat": 50.72048,
    "lon": -1.8795
  }
}
add /protocolSection/contactsLocationsModule/locations/4
Triage: Uncategorized
Uncategorized Operation 20
After
{
  "city": "Doncaster",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Lynda Wyld",
      "role": "CONTACT"
    }
  ],
  "facility": "Doncaster Royal Infirmary",
  "geoPoint": {
    "lat": 53.52285,
    "lon": -1.13116
  }
}
add /protocolSection/contactsLocationsModule/locations/5
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "city": "London",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Alistair Ring",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Royal Marsden NHS Foundation Trust",
  "geoPoint": {
    "lat": 51.50853,
    "lon": -0.12574
  }
}
add /protocolSection/contactsLocationsModule/locations/6
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "city": "London",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Elsa Papadimitraki",
      "role": "CONTACT"
    }
  ],
  "facility": "University College London",
  "geoPoint": {
    "lat": 51.50853,
    "lon": -0.12574
  }
}
add /protocolSection/contactsLocationsModule/locations/7
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "city": "Poole",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Anthony Skene",
      "role": "CONTACT"
    }
  ],
  "facility": "Poole General Hospital",
  "geoPoint": {
    "lat": 50.71429,
    "lon": -1.98458
  }
}
add /protocolSection/contactsLocationsModule/locations/8
Triage: Uncategorized
Uncategorized Operation 24
After
{
  "city": "Wigan",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Elena Takeuchi, MD",
      "role": "CONTACT"
    }
  ],
  "facility": "Royal Albert Edward Infirmary",
  "geoPoint": {
    "lat": 53.54296,
    "lon": -2.63706
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-10
After
2021-06
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 5
Before
2020-10-12
After
2021-06-16
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 6
Before
2020-10-14
After
2021-06-22
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 2 ops
replace /protocolSection/oversightModule/isFdaRegulatedDrug
Triage: Uncategorized
Uncategorized Operation 7
Before
false
After
true
add /protocolSection/oversightModule/isUsExport
Triage: Uncategorized
Uncategorized Operation 8
After
true
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
NOT_YET_RECRUITING
After
RECRUITING
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2021-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2020-12-23"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2021-06-16"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2021-06-22"
  },
  {
    "op": "replace",
    "path": "/protocolSection/oversightModule/isFdaRegulatedDrug",
    "value": true
  },
  {
    "op": "add",
    "path": "/protocolSection/oversightModule/isUsExport",
    "value": true
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/0/facility",
    "value": "Queen Elizabeth Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/0/city",
    "value": "Kings Lynn"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/0/geoPoint/lat",
    "value": 52.75172
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/0/geoPoint/lon",
    "value": 0.39516
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/state",
    "value": "England"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/zip",
    "value": "PE30 4ET"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts",
    "value": [
      {
        "name": "Nicola Ainsworth, MD",
        "role": "CONTACT"
      }
    ]
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1",
    "value": {
      "zip": "SN3 6BB",
      "city": "Swindon",
      "state": "England",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Anne Kendal, MD",
          "role": "CONTACT"
        }
      ],
      "facility": "Great Western Hospital",
      "geoPoint": {
        "lat": 51.55797,
        "lon": -1.78116
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "city": "Aberdeen",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Ravi Sharma, MD",
          "role": "CONTACT"
        }
      ],
      "facility": "Aberdeen Royal Infirmary",
      "geoPoint": {
        "lat": 57.14369,
        "lon": -2.09814
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3",
    "value": {
      "city": "Bournemouth",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Anthony Skene",
          "role": "CONTACT"
        }
      ],
      "facility": "Royal Bournemouth Hospital",
      "geoPoint": {
        "lat": 50.72048,
        "lon": -1.8795
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/4",
    "value": {
      "city": "Doncaster",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Lynda Wyld",
          "role": "CONTACT"
        }
      ],
      "facility": "Doncaster Royal Infirmary",
      "geoPoint": {
        "lat": 53.52285,
        "lon": -1.13116
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/5",
    "value": {
      "city": "London",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Alistair Ring",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Royal Marsden NHS Foundation Trust",
      "geoPoint": {
        "lat": 51.50853,
        "lon": -0.12574
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6",
    "value": {
      "city": "London",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Elsa Papadimitraki",
          "role": "CONTACT"
        }
      ],
      "facility": "University College London",
      "geoPoint": {
        "lat": 51.50853,
        "lon": -0.12574
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/7",
    "value": {
      "city": "Poole",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Anthony Skene",
          "role": "CONTACT"
        }
      ],
      "facility": "Poole General Hospital",
      "geoPoint": {
        "lat": 50.71429,
        "lon": -1.98458
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/8",
    "value": {
      "city": "Wigan",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Elena Takeuchi, MD",
          "role": "CONTACT"
        }
      ],
      "facility": "Royal Albert Edward Infirmary",
      "geoPoint": {
        "lat": 53.54296,
        "lon": -2.63706
      }
    }
  }
]