Back to trial

NCT04584853

PreOperative Endocrine Therapy for Individualised Care With Abemaciclib

Version 1 to 2 · Institute of Cancer Research, United Kingdom

Patch inspector

Version 1 to 2

21 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:44:34+00
Raw hash
0612af039a6611fb96f3d9c662f0416f40d0340145c1e18a330de9893288cf85
Payload
Source URL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 18 ops
replace /protocolSection/contactsLocationsModule/centralContacts/0/name
Triage: Low
Administrative Contact Change Operation 4
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
Peter Chatfield
After
Lorna Smith
add /protocolSection/contactsLocationsModule/locations/0
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "city": "Truro",
  "state": "Cornwall",
  "status": "NOT_YET_RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Duncan Wheatley",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Royal Cornwall Hospital",
  "geoPoint": {
    "lat": 50.26526,
    "lon": -5.05436
  }
}
add /protocolSection/contactsLocationsModule/locations/1
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "city": "Exeter",
  "state": "Devon",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Douglas Ferguson",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Royal Devon & Exeter Hospital",
  "geoPoint": {
    "lat": 50.7236,
    "lon": -3.52751
  }
}
add /protocolSection/contactsLocationsModule/locations/4
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "city": "Northampton",
  "state": "Northants",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Harieta Garofide",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Northampton General Hospital",
  "geoPoint": {
    "lat": 52.25,
    "lon": -0.88333
  }
}
add /protocolSection/contactsLocationsModule/locations/6
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "city": "Bangor",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Catherine Bale",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Ysbyty Gwynedd",
  "geoPoint": {
    "lat": 54.66079,
    "lon": -5.66802
  }
}
add /protocolSection/contactsLocationsModule/locations/7
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "city": "Blackpool",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Pavel Bezecny",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Blackpool Victoria Hospital",
  "geoPoint": {
    "lat": 53.81667,
    "lon": -3.05
  }
}
add /protocolSection/contactsLocationsModule/locations/9
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "city": "Brighton",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Rathi Rathinaezhil",
      "role": "CONTACT"
    }
  ],
  "facility": "Royal Sussex County Hospital",
  "geoPoint": {
    "lat": 50.82838,
    "lon": -0.13947
  }
}
add /protocolSection/contactsLocationsModule/locations/11
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "city": "Dumfries",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Aisling Hennessy",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Dumfries and Galloway Royal Infirmary",
  "geoPoint": {
    "lat": 55.06959,
    "lon": -3.61139
  }
}
add /protocolSection/contactsLocationsModule/locations/12
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "city": "Dundee",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Jane Macaskill",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Ninewells Hospital",
  "geoPoint": {
    "lat": 56.46913,
    "lon": -2.97489
  }
}
add /protocolSection/contactsLocationsModule/locations/13
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "city": "Harrogate",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Biswajit Ray",
      "role": "CONTACT"
    }
  ],
  "facility": "Harrogate District Hospital",
  "geoPoint": {
    "lat": 53.99078,
    "lon": -1.5373
  }
}
add /protocolSection/contactsLocationsModule/locations/14
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "city": "Kingston upon Thames",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Marina Parton",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Kingston Hospital",
  "geoPoint": {
    "lat": 51.41259,
    "lon": -0.2974
  }
}
add /protocolSection/contactsLocationsModule/locations/15
Triage: Uncategorized
Uncategorized Operation 15
After
{
  "city": "London",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Susan Cleator",
      "role": "CONTACT"
    }
  ],
  "facility": "Charing Cross Hospital",
  "geoPoint": {
    "lat": 51.50853,
    "lon": -0.12574
  }
}
add /protocolSection/contactsLocationsModule/locations/16
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "city": "London",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Amna Sheri",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Royal Free Hospital",
  "geoPoint": {
    "lat": 51.50853,
    "lon": -0.12574
  }
}
add /protocolSection/contactsLocationsModule/locations/20
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "city": "Reading",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Madhumita Bhattacharyya",
      "role": "CONTACT"
    }
  ],
  "facility": "Royal Berskhire Hospital",
  "geoPoint": {
    "lat": 51.45625,
    "lon": -0.97113
  }
}
add /protocolSection/contactsLocationsModule/locations/21
Triage: Uncategorized
Uncategorized Operation 18
After
{
  "city": "Redhill",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Jagdeep Singh",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "East Surrey Hospital",
  "geoPoint": {
    "lat": 51.24048,
    "lon": -0.17044
  }
}
add /protocolSection/contactsLocationsModule/locations/22
Triage: Uncategorized
Uncategorized Operation 19
After
{
  "city": "Rhyl",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Jill Bishop",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Glan Clwyd",
  "geoPoint": {
    "lat": 53.31929,
    "lon": -3.49228
  }
}
add /protocolSection/contactsLocationsModule/locations/23
Triage: Uncategorized
Uncategorized Operation 20
After
{
  "city": "Shrewsbury",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Laura Pettit",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Royal Shrewsbury Hospital",
  "geoPoint": {
    "lat": 52.71009,
    "lon": -2.75208
  }
}
add /protocolSection/contactsLocationsModule/locations/24
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "WF1 4DG",
  "city": "Wakefield",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United Kingdom",
  "facility": "Mid Yorkshire -Pinderfields Hospital",
  "geoPoint": {
    "lat": 53.68331,
    "lon": -1.49768
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2021-06
After
2022-02
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2021-06-16
After
2022-02-16
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2021-06-22
After
2022-02-17
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2022-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2022-02-16"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2022-02-17"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/name",
    "value": "Lorna Smith"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0",
    "value": {
      "city": "Truro",
      "state": "Cornwall",
      "status": "NOT_YET_RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Duncan Wheatley",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Royal Cornwall Hospital",
      "geoPoint": {
        "lat": 50.26526,
        "lon": -5.05436
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1",
    "value": {
      "city": "Exeter",
      "state": "Devon",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Douglas Ferguson",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Royal Devon & Exeter Hospital",
      "geoPoint": {
        "lat": 50.7236,
        "lon": -3.52751
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/4",
    "value": {
      "city": "Northampton",
      "state": "Northants",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Harieta Garofide",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Northampton General Hospital",
      "geoPoint": {
        "lat": 52.25,
        "lon": -0.88333
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6",
    "value": {
      "city": "Bangor",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Catherine Bale",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Ysbyty Gwynedd",
      "geoPoint": {
        "lat": 54.66079,
        "lon": -5.66802
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/7",
    "value": {
      "city": "Blackpool",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Pavel Bezecny",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Blackpool Victoria Hospital",
      "geoPoint": {
        "lat": 53.81667,
        "lon": -3.05
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/9",
    "value": {
      "city": "Brighton",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Rathi Rathinaezhil",
          "role": "CONTACT"
        }
      ],
      "facility": "Royal Sussex County Hospital",
      "geoPoint": {
        "lat": 50.82838,
        "lon": -0.13947
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/11",
    "value": {
      "city": "Dumfries",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Aisling Hennessy",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Dumfries and Galloway Royal Infirmary",
      "geoPoint": {
        "lat": 55.06959,
        "lon": -3.61139
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/12",
    "value": {
      "city": "Dundee",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Jane Macaskill",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Ninewells Hospital",
      "geoPoint": {
        "lat": 56.46913,
        "lon": -2.97489
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/13",
    "value": {
      "city": "Harrogate",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Biswajit Ray",
          "role": "CONTACT"
        }
      ],
      "facility": "Harrogate District Hospital",
      "geoPoint": {
        "lat": 53.99078,
        "lon": -1.5373
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/14",
    "value": {
      "city": "Kingston upon Thames",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Marina Parton",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Kingston Hospital",
      "geoPoint": {
        "lat": 51.41259,
        "lon": -0.2974
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/15",
    "value": {
      "city": "London",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Susan Cleator",
          "role": "CONTACT"
        }
      ],
      "facility": "Charing Cross Hospital",
      "geoPoint": {
        "lat": 51.50853,
        "lon": -0.12574
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/16",
    "value": {
      "city": "London",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Amna Sheri",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Royal Free Hospital",
      "geoPoint": {
        "lat": 51.50853,
        "lon": -0.12574
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/20",
    "value": {
      "city": "Reading",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Madhumita Bhattacharyya",
          "role": "CONTACT"
        }
      ],
      "facility": "Royal Berskhire Hospital",
      "geoPoint": {
        "lat": 51.45625,
        "lon": -0.97113
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/21",
    "value": {
      "city": "Redhill",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Jagdeep Singh",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "East Surrey Hospital",
      "geoPoint": {
        "lat": 51.24048,
        "lon": -0.17044
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/22",
    "value": {
      "city": "Rhyl",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Jill Bishop",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Glan Clwyd",
      "geoPoint": {
        "lat": 53.31929,
        "lon": -3.49228
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/23",
    "value": {
      "city": "Shrewsbury",
      "status": "RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Laura Pettit",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Royal Shrewsbury Hospital",
      "geoPoint": {
        "lat": 52.71009,
        "lon": -2.75208
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/24",
    "value": {
      "zip": "WF1 4DG",
      "city": "Wakefield",
      "status": "ACTIVE_NOT_RECRUITING",
      "country": "United Kingdom",
      "facility": "Mid Yorkshire -Pinderfields Hospital",
      "geoPoint": {
        "lat": 53.68331,
        "lon": -1.49768
      }
    }
  }
]