Back to trial

NCT04588246

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Version 0 to 1 · NRG Oncology

Patch inspector

Version 0 to 1

7 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_actualized_earlier",
    "category": "timeline_actualized_earlier",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2020-12-15",
    "old_value": "2021-03-05",
    "delta_days": 80,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:57:22+00
Raw hash
c11b5af9116ec12f9c70cff486a44394e59d8c2495dfc59a23ce50f44c46f1dd
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2021-03-05
After
2020-12-15
replace /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 1 ops
add /protocolSection/contactsLocationsModule/locations
Triage: Uncategorized
Uncategorized Operation 7
After
[
  {
    "zip": "21201",
    "city": "Baltimore",
    "state": "Maryland",
    "status": "RECRUITING",
    "country": "United States",
    "contacts": [
      {
        "name": "Site Public Contact",
        "role": "CONTACT",
        "phone": "800-888-8823"
      },
      {
        "name": "Mark V. Mishra",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ],
    "facility": "University of Maryland/Greenebaum Cancer Center",
    "geoPoint": {
      "lat": 39.29038,
      "lon": -76.61219
    }
  },
  {
    "zip": "21014",
    "city": "Bel Air",
    "state": "Maryland",
    "status": "RECRUITING",
    "country": "United States",
    "contacts": [
      {
        "name": "Site Public Contact",
        "role": "CONTACT",
        "phone": "443-643-3010"
      },
      {
        "name": "Matthew J. Ferris",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ],
    "facility": "UM Upper Chesapeake Medical Center",
    "geoPoint": {
      "lat": 39.53594,
      "lon": -76.34829
    }
  },
  {
    "zip": "21044",
    "city": "Columbia",
    "state": "Maryland",
    "status": "RECRUITING",
    "country": "United States",
    "contacts": [
      {
        "name": "Site Public Contact",
        "role": "CONTACT",
        "phone": "443-546-1300"
      },
      {
        "name": "Mark V. Mishra",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ],
    "facility": "Central Maryland Radiation Oncology in Howard County",
    "geoPoint": {
      "lat": 39.24038,
      "lon": -76.83942
    }
  },
  {
    "zip": "21061",
    "city": "Glen Burnie",
    "state": "Maryland",
    "status": "RECRUITING",
    "country": "United States",
    "contacts": [
      {
        "name": "Site Public Contact",
        "role": "CONTACT",
        "phone": "410-553-8100"
      },
      {
        "name": "Mark V. Mishra",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ],
    "facility": "UM Baltimore Washington Medical Center/Tate Cancer Center",
    "geoPoint": {
      "lat": 39.16261,
      "lon": -76.62469
    }
  },
  {
    "zip": "73104",
    "city": "Oklahoma City",
    "state": "Oklahoma",
    "status": "RECRUITING",
    "country": "United States",
    "contacts": [
      {
        "name": "Site Public Contact",
        "role": "CONTACT",
        "email": "ou-clinical-trials@ouhsc.edu",
        "phone": "405-271-8777"
      },
      {
        "name": "Tyler Gunter",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ],
    "facility": "University of Oklahoma Health Sciences Center",
    "geoPoint": {
      "lat": 35.46756,
      "lon": -97.51643
    }
  },
  {
    "zip": "29605",
    "city": "Greenville",
    "state": "South Carolina",
    "status": "RECRUITING",
    "country": "United States",
    "contacts": [
      {
        "name": "Site Public Contact",
        "role": "CONTACT",
        "email": "kim.williams3@prismahealth.org",
        "phone": "864-522-2066"
      },
      {
        "name": "Emory McTyre",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ],
    "facility": "Prisma Health Cancer Institute - Faris",
    "geoPoint": {
      "lat": 34.85262,
      "lon": -82.39401
    }
  }
]
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-10
After
2021-02
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 5
Before
2020-10-13
After
2021-02-26
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 6
Before
2020-10-19
After
2021-03-01
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
NOT_YET_RECRUITING
After
RECRUITING
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2021-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2020-12-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2021-02-26"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2021-03-01"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations",
    "value": [
      {
        "zip": "21201",
        "city": "Baltimore",
        "state": "Maryland",
        "status": "RECRUITING",
        "country": "United States",
        "contacts": [
          {
            "name": "Site Public Contact",
            "role": "CONTACT",
            "phone": "800-888-8823"
          },
          {
            "name": "Mark V. Mishra",
            "role": "PRINCIPAL_INVESTIGATOR"
          }
        ],
        "facility": "University of Maryland/Greenebaum Cancer Center",
        "geoPoint": {
          "lat": 39.29038,
          "lon": -76.61219
        }
      },
      {
        "zip": "21014",
        "city": "Bel Air",
        "state": "Maryland",
        "status": "RECRUITING",
        "country": "United States",
        "contacts": [
          {
            "name": "Site Public Contact",
            "role": "CONTACT",
            "phone": "443-643-3010"
          },
          {
            "name": "Matthew J. Ferris",
            "role": "PRINCIPAL_INVESTIGATOR"
          }
        ],
        "facility": "UM Upper Chesapeake Medical Center",
        "geoPoint": {
          "lat": 39.53594,
          "lon": -76.34829
        }
      },
      {
        "zip": "21044",
        "city": "Columbia",
        "state": "Maryland",
        "status": "RECRUITING",
        "country": "United States",
        "contacts": [
          {
            "name": "Site Public Contact",
            "role": "CONTACT",
            "phone": "443-546-1300"
          },
          {
            "name": "Mark V. Mishra",
            "role": "PRINCIPAL_INVESTIGATOR"
          }
        ],
        "facility": "Central Maryland Radiation Oncology in Howard County",
        "geoPoint": {
          "lat": 39.24038,
          "lon": -76.83942
        }
      },
      {
        "zip": "21061",
        "city": "Glen Burnie",
        "state": "Maryland",
        "status": "RECRUITING",
        "country": "United States",
        "contacts": [
          {
            "name": "Site Public Contact",
            "role": "CONTACT",
            "phone": "410-553-8100"
          },
          {
            "name": "Mark V. Mishra",
            "role": "PRINCIPAL_INVESTIGATOR"
          }
        ],
        "facility": "UM Baltimore Washington Medical Center/Tate Cancer Center",
        "geoPoint": {
          "lat": 39.16261,
          "lon": -76.62469
        }
      },
      {
        "zip": "73104",
        "city": "Oklahoma City",
        "state": "Oklahoma",
        "status": "RECRUITING",
        "country": "United States",
        "contacts": [
          {
            "name": "Site Public Contact",
            "role": "CONTACT",
            "email": "ou-clinical-trials@ouhsc.edu",
            "phone": "405-271-8777"
          },
          {
            "name": "Tyler Gunter",
            "role": "PRINCIPAL_INVESTIGATOR"
          }
        ],
        "facility": "University of Oklahoma Health Sciences Center",
        "geoPoint": {
          "lat": 35.46756,
          "lon": -97.51643
        }
      },
      {
        "zip": "29605",
        "city": "Greenville",
        "state": "South Carolina",
        "status": "RECRUITING",
        "country": "United States",
        "contacts": [
          {
            "name": "Site Public Contact",
            "role": "CONTACT",
            "email": "kim.williams3@prismahealth.org",
            "phone": "864-522-2066"
          },
          {
            "name": "Emory McTyre",
            "role": "PRINCIPAL_INVESTIGATOR"
          }
        ],
        "facility": "Prisma Health Cancer Institute - Faris",
        "geoPoint": {
          "lat": 34.85262,
          "lon": -82.39401
        }
      }
    ]
  }
]