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NCT04923542

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

Version 15 to 16 · H. Lee Moffitt Cancer Center and Research Institute

Patch inspector

Version 15 to 16

7 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2026-11-05",
    "old_value": "2026-03",
    "delta_days": 249,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2026-12",
    "old_value": "2026-03",
    "delta_days": 275,
    "date_struct": "completionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:29+00
Raw hash
566d66c30da9f70bcb4db0217aeb598070448111fe443a10557653755fc6e99f
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2026-03
After
2026-11-05
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2026-03
After
2026-12
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 2 ops
replace /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 6
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/0/contacts
Triage: Uncategorized
Uncategorized Operation 7
Before
[
  {
    "name": "Robin Dowell",
    "role": "CONTACT",
    "email": "Robin.Dowell@moffitt.org",
    "phone": "813-745-0393"
  },
  {
    "name": "Avan Armaghani, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "John Arrington, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Ricardo Costa, MD, MSc",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Arnold Etame, MD, PhD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Peter Forsyth, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Hung Khong, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "James Liu, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Daniel Oliver, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Marilin Rosa, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Hatem Soliman, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Aixa Soyano Muller, MD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Nam Tran, MD, PhD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Michael Vogelbaum, MD, PhD",
    "role": "SUB_INVESTIGATOR"
  },
  {
    "name": "Michael Yu, MD",
    "role": "SUB_INVESTIGATOR"
  }
]
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2025-11
After
2026-02
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2025-11-11
After
2026-02-04
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2025-11-13
After
2026-02-06
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2026-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2026-11-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2026-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2026-02-04"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2026-02-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts"
  }
]