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NCT05460273

A Study of Dato-DXd in Chinese Patients With Advanced Non-Small Cell Lung Cancer, Triple-negative Breast Cancer and Other Solid Tumors (TROPION-PanTumor02)

Version 11 to 12 · AstraZeneca

Patch inspector

Version 11 to 12

5 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2024-12-30",
    "old_value": "2024-05-06",
    "delta_days": 238,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:57:51+00
Raw hash
5af46ad5c50e9afc5fbd9868600d1164fdd0df3f492467cd52b1481804fc5c5a
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2024-05-06
After
2024-12-30
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2024-03
After
2024-08
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2024-04-16
After
2024-09-20
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2024-04-17
After
2024-09-23
add /annotationSection
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "annotationModule": {
    "unpostedAnnotation": {
      "unpostedEvents": [
        {
          "date": "2024-10-31",
          "type": "RELEASE"
        },
        {
          "date": "2024-12-16",
          "type": "RESET"
        },
        {
          "date": "2025-03-06",
          "type": "RELEASE"
        },
        {
          "date": "2025-03-25",
          "type": "RESET"
        },
        {
          "date": "2025-04-22",
          "type": "RELEASE"
        },
        {
          "date": "2025-05-06",
          "type": "RESET"
        }
      ],
      "unpostedResponsibleParty": "AstraZeneca"
    }
  }
}
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2024-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2024-12-30"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2024-09-20"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2024-09-23"
  },
  {
    "op": "add",
    "path": "/annotationSection",
    "value": {
      "annotationModule": {
        "unpostedAnnotation": {
          "unpostedEvents": [
            {
              "date": "2024-10-31",
              "type": "RELEASE"
            },
            {
              "date": "2024-12-16",
              "type": "RESET"
            },
            {
              "date": "2025-03-06",
              "type": "RELEASE"
            },
            {
              "date": "2025-03-25",
              "type": "RESET"
            },
            {
              "date": "2025-04-22",
              "type": "RELEASE"
            },
            {
              "date": "2025-05-06",
              "type": "RESET"
            }
          ],
          "unpostedResponsibleParty": "AstraZeneca"
        }
      }
    }
  }
]