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NCT05549505

A Trial Using ARV-471 or Anastrozole in Post-Menopausal Women With Breast Cancer Prior to Surgery

Version 1 to 2 · Arvinas Inc.

Patch inspector

Version 1 to 2

26 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2023-02-15",
    "old_value": "2023-01",
    "delta_days": 45,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:37+00
Raw hash
6294d9da24e921e44ff2ef1b486d7168ba11e6576c70aa09de0d190c721341ea
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2023-01
After
2023-02-15
replace /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 21 ops
add /protocolSection/contactsLocationsModule/locations/0
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "72762",
  "city": "Springdale",
  "state": "Arkansas",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 36.18674,
    "lon": -94.12881
  }
}
add /protocolSection/contactsLocationsModule/locations/1
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "91405",
  "city": "Van Nuys",
  "state": "California",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 34.18667,
    "lon": -118.44897
  }
}
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "33308",
  "city": "Fort Lauderdale",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 26.12231,
    "lon": -80.14338
  }
}
add /protocolSection/contactsLocationsModule/locations/3
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "33901",
  "city": "Fort Myers",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 26.62168,
    "lon": -81.84059
  }
}
add /protocolSection/contactsLocationsModule/locations/4
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "33401",
  "city": "West Palm Beach",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 26.71534,
    "lon": -80.05337
  }
}
add /protocolSection/contactsLocationsModule/locations/6
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "zip": "37203",
  "city": "Nashville",
  "state": "Tennessee",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 36.16589,
    "lon": -86.78444
  }
}
add /protocolSection/contactsLocationsModule/locations/7
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "98405",
  "city": "Tacoma",
  "state": "Washington",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 47.25288,
    "lon": -122.44429
  }
}
add /protocolSection/contactsLocationsModule/locations/8
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "6000",
  "city": "Batumi",
  "status": "RECRUITING",
  "country": "Georgia",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 41.64077,
    "lon": 41.6306
  }
}
add /protocolSection/contactsLocationsModule/locations/9
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "0112",
  "city": "Tbilisi",
  "status": "RECRUITING",
  "country": "Georgia",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 41.69143,
    "lon": 44.83412
  }
}
add /protocolSection/contactsLocationsModule/locations/10
Triage: Uncategorized
Uncategorized Operation 15
After
{
  "zip": "0144",
  "city": "Tbilisi",
  "status": "RECRUITING",
  "country": "Georgia",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 41.69143,
    "lon": 44.83412
  }
}
add /protocolSection/contactsLocationsModule/locations/11
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "zip": "0159",
  "city": "Tbilisi",
  "status": "RECRUITING",
  "country": "Georgia",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 41.69143,
    "lon": 44.83412
  }
}
add /protocolSection/contactsLocationsModule/locations/12
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "53111",
  "city": "Bonn",
  "status": "RECRUITING",
  "country": "Germany",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 50.73438,
    "lon": 7.09549
  }
}
add /protocolSection/contactsLocationsModule/locations/13
Triage: Uncategorized
Uncategorized Operation 18
After
{
  "zip": "91054",
  "city": "Erlangen",
  "status": "RECRUITING",
  "country": "Germany",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 49.59099,
    "lon": 11.00783
  }
}
add /protocolSection/contactsLocationsModule/locations/14
Triage: Uncategorized
Uncategorized Operation 19
After
{
  "zip": "15006",
  "city": "A Coruña",
  "state": "Galicia",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 43.37135,
    "lon": -8.396
  }
}
add /protocolSection/contactsLocationsModule/locations/15
Triage: Uncategorized
Uncategorized Operation 20
After
{
  "zip": "03010",
  "city": "Alicante",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 38.34517,
    "lon": -0.48149
  }
}
add /protocolSection/contactsLocationsModule/locations/16
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "08025",
  "city": "Barcelona",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 41.38879,
    "lon": 2.15899
  }
}
add /protocolSection/contactsLocationsModule/locations/17
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "zip": "08036",
  "city": "Barcelona",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 41.38879,
    "lon": 2.15899
  }
}
add /protocolSection/contactsLocationsModule/locations/18
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "zip": "18005",
  "city": "Granada",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 37.18817,
    "lon": -3.60667
  }
}
add /protocolSection/contactsLocationsModule/locations/19
Triage: Uncategorized
Uncategorized Operation 24
After
{
  "zip": "18014",
  "city": "Granada",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 37.18817,
    "lon": -3.60667
  }
}
add /protocolSection/contactsLocationsModule/locations/20
Triage: Uncategorized
Uncategorized Operation 25
After
{
  "zip": "28034",
  "city": "Madrid",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 40.4165,
    "lon": -3.70256
  }
}
add /protocolSection/contactsLocationsModule/locations/21
Triage: Uncategorized
Uncategorized Operation 26
After
{
  "zip": "46009",
  "city": "Valencia",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 39.47391,
    "lon": -0.37966
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2023-01
After
2023-03
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2023-01-26
After
2023-03-30
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2023-01-27
After
2023-03-31
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2023-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2023-02-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2023-03-30"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2023-03-31"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0",
    "value": {
      "zip": "72762",
      "city": "Springdale",
      "state": "Arkansas",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 36.18674,
        "lon": -94.12881
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1",
    "value": {
      "zip": "91405",
      "city": "Van Nuys",
      "state": "California",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 34.18667,
        "lon": -118.44897
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "zip": "33308",
      "city": "Fort Lauderdale",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 26.12231,
        "lon": -80.14338
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3",
    "value": {
      "zip": "33901",
      "city": "Fort Myers",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 26.62168,
        "lon": -81.84059
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/4",
    "value": {
      "zip": "33401",
      "city": "West Palm Beach",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 26.71534,
        "lon": -80.05337
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6",
    "value": {
      "zip": "37203",
      "city": "Nashville",
      "state": "Tennessee",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 36.16589,
        "lon": -86.78444
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/7",
    "value": {
      "zip": "98405",
      "city": "Tacoma",
      "state": "Washington",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 47.25288,
        "lon": -122.44429
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/8",
    "value": {
      "zip": "6000",
      "city": "Batumi",
      "status": "RECRUITING",
      "country": "Georgia",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 41.64077,
        "lon": 41.6306
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/9",
    "value": {
      "zip": "0112",
      "city": "Tbilisi",
      "status": "RECRUITING",
      "country": "Georgia",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 41.69143,
        "lon": 44.83412
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/10",
    "value": {
      "zip": "0144",
      "city": "Tbilisi",
      "status": "RECRUITING",
      "country": "Georgia",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 41.69143,
        "lon": 44.83412
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/11",
    "value": {
      "zip": "0159",
      "city": "Tbilisi",
      "status": "RECRUITING",
      "country": "Georgia",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 41.69143,
        "lon": 44.83412
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/12",
    "value": {
      "zip": "53111",
      "city": "Bonn",
      "status": "RECRUITING",
      "country": "Germany",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 50.73438,
        "lon": 7.09549
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/13",
    "value": {
      "zip": "91054",
      "city": "Erlangen",
      "status": "RECRUITING",
      "country": "Germany",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 49.59099,
        "lon": 11.00783
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/14",
    "value": {
      "zip": "15006",
      "city": "A Coruña",
      "state": "Galicia",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 43.37135,
        "lon": -8.396
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/15",
    "value": {
      "zip": "03010",
      "city": "Alicante",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 38.34517,
        "lon": -0.48149
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/16",
    "value": {
      "zip": "08025",
      "city": "Barcelona",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 41.38879,
        "lon": 2.15899
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/17",
    "value": {
      "zip": "08036",
      "city": "Barcelona",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 41.38879,
        "lon": 2.15899
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/18",
    "value": {
      "zip": "18005",
      "city": "Granada",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 37.18817,
        "lon": -3.60667
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/19",
    "value": {
      "zip": "18014",
      "city": "Granada",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 37.18817,
        "lon": -3.60667
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/20",
    "value": {
      "zip": "28034",
      "city": "Madrid",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 40.4165,
        "lon": -3.70256
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/21",
    "value": {
      "zip": "46009",
      "city": "Valencia",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 39.47391,
        "lon": -0.37966
      }
    }
  }
]