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NCT05549505

A Trial Using ARV-471 or Anastrozole in Post-Menopausal Women With Breast Cancer Prior to Surgery

Version 2 to 3 · Arvinas Inc.

Patch inspector

Version 2 to 3

14 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2024-07-15",
    "old_value": "2023-12",
    "delta_days": 227,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2024-08-15",
    "old_value": "2024-06",
    "delta_days": 75,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:37+00
Raw hash
e685ab7333bdc30536d4b1f0242bbb32bd27f50e16db822eb2a3d7a63c519e00
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
replace /protocolSection/armsInterventionsModule/interventions/2/description
Triage: High
Arm Intervention Change Operation 7
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Participants will have surgical resection approximately 5.5 months after starting treatment (C6D18 ± 10 days)
After
Participants will have surgical resection approximately 5.5 months after starting treatment (C6D18 ± 14 days)
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2023-12
After
2024-07-15
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2024-06
After
2024-08-15
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 7 ops
add /protocolSection/contactsLocationsModule/locations/1
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "90505",
  "city": "Torrance",
  "state": "California",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 33.83585,
    "lon": -118.34063
  }
}
add /protocolSection/contactsLocationsModule/locations/5
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "32806",
  "city": "Orlando",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 28.53834,
    "lon": -81.37924
  }
}
add /protocolSection/contactsLocationsModule/locations/14
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "13125",
  "city": "Berlin",
  "status": "RECRUITING",
  "country": "Germany",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 52.52437,
    "lon": 13.41053
  }
}
add /protocolSection/contactsLocationsModule/locations/16
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "zip": "46236",
  "city": "Bottrop",
  "status": "RECRUITING",
  "country": "Germany",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 51.52392,
    "lon": 6.9285
  }
}
add /protocolSection/contactsLocationsModule/locations/18
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "73730",
  "city": "Esslingen am Neckar",
  "status": "RECRUITING",
  "country": "Germany",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 48.73961,
    "lon": 9.30473
  }
}
add /protocolSection/contactsLocationsModule/locations/23
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "14004",
  "city": "Córdoba",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 37.89155,
    "lon": -4.77275
  }
}
add /protocolSection/contactsLocationsModule/locations/27
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "41013",
  "city": "Seville",
  "status": "RECRUITING",
  "country": "Spain",
  "facility": "Clinical Trial Site",
  "geoPoint": {
    "lat": 37.38283,
    "lon": -5.97317
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2023-03
After
2023-06
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2023-03-30
After
2023-06-13
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2023-03-31
After
2023-06-15
add /protocolSection/conditionsModule/keywords/18
Triage: Uncategorized
Uncategorized Operation 6
After
Vepdegestrant
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2023-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2024-07-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2024-08-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2023-06-13"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2023-06-15"
  },
  {
    "op": "add",
    "path": "/protocolSection/conditionsModule/keywords/18",
    "value": "Vepdegestrant"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/2/description",
    "value": "Participants will have surgical resection approximately 5.5 months after starting treatment (C6D18 ± 14 days)"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1",
    "value": {
      "zip": "90505",
      "city": "Torrance",
      "state": "California",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 33.83585,
        "lon": -118.34063
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/5",
    "value": {
      "zip": "32806",
      "city": "Orlando",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 28.53834,
        "lon": -81.37924
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/14",
    "value": {
      "zip": "13125",
      "city": "Berlin",
      "status": "RECRUITING",
      "country": "Germany",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 52.52437,
        "lon": 13.41053
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/16",
    "value": {
      "zip": "46236",
      "city": "Bottrop",
      "status": "RECRUITING",
      "country": "Germany",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 51.52392,
        "lon": 6.9285
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/18",
    "value": {
      "zip": "73730",
      "city": "Esslingen am Neckar",
      "status": "RECRUITING",
      "country": "Germany",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 48.73961,
        "lon": 9.30473
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/23",
    "value": {
      "zip": "14004",
      "city": "Córdoba",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 37.89155,
        "lon": -4.77275
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/27",
    "value": {
      "zip": "41013",
      "city": "Seville",
      "status": "RECRUITING",
      "country": "Spain",
      "facility": "Clinical Trial Site",
      "geoPoint": {
        "lat": 37.38283,
        "lon": -5.97317
      }
    }
  }
]