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NCT05549505

A Trial Using ARV-471 or Anastrozole in Post-Menopausal Women With Breast Cancer Prior to Surgery

Version 4 to 5 · Arvinas Inc.

Patch inspector

Version 4 to 5

56 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_changeenrollment_count_changeenrollment_type_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:37+00
Raw hash
35c3098711d4e077476240f134c506acfb5afd2cb99488470af0c5cd648b65de
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 2 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 5
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
150
After
152
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 6
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 50 ops
remove /protocolSection/contactsLocationsModule/centralContacts
Triage: Low
Administrative Contact Change Operation 7
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
[
  {
    "name": "Arvinas Estrogen Receptor, Inc.",
    "role": "CONTACT",
    "email": "clinicaltrialsARV-471@arvinas.com",
    "phone": "475-345-3366"
  }
]
remove /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 8
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1/status
Triage: Uncategorized
Uncategorized Operation 9
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/2/status
Triage: Uncategorized
Uncategorized Operation 10
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/3/status
Triage: Uncategorized
Uncategorized Operation 11
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/4/status
Triage: Uncategorized
Uncategorized Operation 12
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/5/status
Triage: Uncategorized
Uncategorized Operation 13
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/6/status
Triage: Uncategorized
Uncategorized Operation 14
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/7/status
Triage: Uncategorized
Uncategorized Operation 15
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/8/status
Triage: Uncategorized
Uncategorized Operation 16
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/9/status
Triage: Uncategorized
Uncategorized Operation 17
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/10/status
Triage: Uncategorized
Uncategorized Operation 18
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/11/status
Triage: Uncategorized
Uncategorized Operation 19
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/12/status
Triage: Uncategorized
Uncategorized Operation 20
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/13/status
Triage: Uncategorized
Uncategorized Operation 21
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/14/status
Triage: Uncategorized
Uncategorized Operation 22
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/15/status
Triage: Uncategorized
Uncategorized Operation 23
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/16/status
Triage: Uncategorized
Uncategorized Operation 24
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/17/status
Triage: Uncategorized
Uncategorized Operation 25
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/18/status
Triage: Uncategorized
Uncategorized Operation 26
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/19/status
Triage: Uncategorized
Uncategorized Operation 27
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/20/status
Triage: Uncategorized
Uncategorized Operation 28
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/21/status
Triage: Uncategorized
Uncategorized Operation 29
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/22/status
Triage: Uncategorized
Uncategorized Operation 30
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/23/status
Triage: Uncategorized
Uncategorized Operation 31
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/24/status
Triage: Uncategorized
Uncategorized Operation 32
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/25/status
Triage: Uncategorized
Uncategorized Operation 33
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/26/status
Triage: Uncategorized
Uncategorized Operation 34
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/27/status
Triage: Uncategorized
Uncategorized Operation 35
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/28/status
Triage: Uncategorized
Uncategorized Operation 36
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/29/status
Triage: Uncategorized
Uncategorized Operation 37
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/30/status
Triage: Uncategorized
Uncategorized Operation 38
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/31/status
Triage: Uncategorized
Uncategorized Operation 39
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/32/status
Triage: Uncategorized
Uncategorized Operation 40
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/33/status
Triage: Uncategorized
Uncategorized Operation 41
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/34/status
Triage: Uncategorized
Uncategorized Operation 42
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/35/status
Triage: Uncategorized
Uncategorized Operation 43
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/36/status
Triage: Uncategorized
Uncategorized Operation 44
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/37/status
Triage: Uncategorized
Uncategorized Operation 45
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/38/status
Triage: Uncategorized
Uncategorized Operation 46
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/39/status
Triage: Uncategorized
Uncategorized Operation 47
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/40/status
Triage: Uncategorized
Uncategorized Operation 48
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/41/status
Triage: Uncategorized
Uncategorized Operation 49
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/42/status
Triage: Uncategorized
Uncategorized Operation 50
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/43/status
Triage: Uncategorized
Uncategorized Operation 51
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/44/status
Triage: Uncategorized
Uncategorized Operation 52
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/45/status
Triage: Uncategorized
Uncategorized Operation 53
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/46/status
Triage: Uncategorized
Uncategorized Operation 54
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/47/status
Triage: Uncategorized
Uncategorized Operation 55
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/48/status
Triage: Uncategorized
Uncategorized Operation 56
Before
RECRUITING
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2023-10
After
2024-01
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2023-10-26
After
2024-01-19
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2023-10-27
After
2024-01-22
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2024-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2024-01-19"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2024-01-22"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 152
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/centralContacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/2/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/3/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/5/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/7/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/8/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/9/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/10/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/11/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/12/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/13/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/14/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/15/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/16/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/17/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/18/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/19/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/20/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/21/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/22/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/23/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/24/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/25/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/26/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/27/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/28/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/29/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/30/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/31/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/32/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/33/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/34/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/35/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/36/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/37/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/38/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/39/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/40/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/41/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/42/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/43/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/44/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/45/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/46/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/47/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/48/status"
  }
]