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NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 27 to 28 · Bayer

Patch inspector

Version 27 to 28

5 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:20+00
Raw hash
a68ccb62d34dedbf0525c40e1321543f4fbc810b596c92c9a72eb8749067dd3b
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
replace /protocolSection/armsInterventionsModule/armGroups/7/description
Triage: High
Arm Intervention Change Operation 3
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Patients with breast cancer, kidney cancer, squamous cell cancer of head or neck, melanoma or ovarian solid tumors harboring NTRK fusions.
After
Patients with breast cancer, kidney cancer, squamous cell cancer of head or neck, melanoma or ovarian solid tumors harboring NTRK fusions
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 2 ops
add /protocolSection/contactsLocationsModule/locations/29
Triage: Uncategorized
Uncategorized Operation 4
After
{
  "zip": "466-8560",
  "city": "Nagoya",
  "state": "Aichi-ken",
  "status": "NOT_YET_RECRUITING",
  "country": "Japan",
  "facility": "Nagoya University Hospital",
  "geoPoint": {
    "lat": 35.18147,
    "lon": 136.90641
  }
}
add /protocolSection/contactsLocationsModule/locations/31
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "811-1395",
  "city": "Fukuoka",
  "status": "NOT_YET_RECRUITING",
  "country": "Japan",
  "facility": "National Hospital Organization Kyushu Cancer Center",
  "geoPoint": {
    "lat": 33.6,
    "lon": 130.41667
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2019-08-02
After
2019-08-30
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2019-08-05
After
2019-09-04
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2019-08-30"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2019-09-04"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/7/description",
    "value": "Patients with breast cancer, kidney cancer, squamous cell cancer of head or neck, melanoma or ovarian solid tumors harboring NTRK fusions"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/29",
    "value": {
      "zip": "466-8560",
      "city": "Nagoya",
      "state": "Aichi-ken",
      "status": "NOT_YET_RECRUITING",
      "country": "Japan",
      "facility": "Nagoya University Hospital",
      "geoPoint": {
        "lat": 35.18147,
        "lon": 136.90641
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/31",
    "value": {
      "zip": "811-1395",
      "city": "Fukuoka",
      "status": "NOT_YET_RECRUITING",
      "country": "Japan",
      "facility": "National Hospital Organization Kyushu Cancer Center",
      "geoPoint": {
        "lat": 33.6,
        "lon": 130.41667
      }
    }
  }
]