Back to feed

NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

A Study to Learn How Well the Drug Larotrectinib Works in Adults With Different Solid Cancers With a Change in the Genes Called NTRK Fusion

ClinicalTrials.gov
Sponsor
Bayer
Status
Completed
Versions
97
Adjacent patches
96
Severity is deterministic, reproducible, uncalibrated triage metadata, not validated review priority or proven wrongdoing. New Evidence Record packages are generated for deterministic event-class membership, not by triage rank alone.

Material event timeline

22 shown
Triage: Low
2015-12-04
Administrative Contact Change
v0 to v1 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/centralContacts/0/email
/protocolSection/contactsLocationsModule/centralContacts/0/name
/protocolSection/contactsLocationsModule/centralContacts/1/email
Triage: Low
2016-01-26
Administrative Contact Change
v1 to v2 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/centralContacts/1/email
/protocolSection/contactsLocationsModule/centralContacts/1/name
/protocolSection/contactsLocationsModule/centralContacts/1/phone
Triage: Critical
2017-05-26
Primary Outcome Change
v16 to v17 Early Recruitment Inspect patch
/protocolSection/conditionsModule/conditions/15
/protocolSection/conditionsModule/conditions/16
/protocolSection/conditionsModule/conditions/17
Triage: Critical
2018-08-31
Primary Outcome Change
v19 to v20 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/0/description
/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0
/protocolSection/armsInterventionsModule/armGroups/1/description
Triage: Critical
2019-02-25
Primary Outcome Change
v21 to v22 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/0/description
/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0
/protocolSection/armsInterventionsModule/armGroups/0/label
Triage: High
2019-08-30
Arm Intervention Change
v27 to v28 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/7/description
/protocolSection/contactsLocationsModule/locations/29
/protocolSection/contactsLocationsModule/locations/31
Triage: Critical
2019-12-09
Primary Outcome Change
v30 to v31 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/0/description
/protocolSection/armsInterventionsModule/armGroups/1/description
/protocolSection/armsInterventionsModule/armGroups/10
Triage: Critical
2020-01-10
Primary Outcome Change
v31 to v32 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/37/status
/protocolSection/contactsLocationsModule/locations/42
/protocolSection/contactsLocationsModule/locations/43
Triage: High
2020-03-02
Enrollment Change
v33 to v34 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/21
/protocolSection/contactsLocationsModule/locations/22
/protocolSection/designModule/enrollmentInfo/count
Triage: Medium
2020-06-03
Timeline Shift
v35 to v36 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/22
/protocolSection/contactsLocationsModule/locations/25
/protocolSection/contactsLocationsModule/locations/26
Triage: High
2020-07-02
Secondary Outcome Change
v36 to v37 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/22/status
/protocolSection/contactsLocationsModule/locations/44/status
/protocolSection/contactsLocationsModule/locations/46/status
Triage: High
2021-05-27
Eligibility Change
v47 to v48 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/104/status
/protocolSection/contactsLocationsModule/locations/112/status
/protocolSection/contactsLocationsModule/locations/142/status
Triage: High
2021-08-05
Eligibility Change
v49 to v50 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/112/status
/protocolSection/contactsLocationsModule/locations/118/status
/protocolSection/contactsLocationsModule/locations/142/status
Triage: High
2021-10-18
Arm Intervention Change
v51 to v52 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/10
/protocolSection/armsInterventionsModule/armGroups/9/description
/protocolSection/armsInterventionsModule/armGroups/9/label
Triage: High
2022-03-28
Arm Intervention Change
v55 to v56 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/10
/protocolSection/armsInterventionsModule/armGroups/3/description
/protocolSection/armsInterventionsModule/armGroups/7/description
Triage: Medium
2023-02-17
Timeline Major Slip
v67 to v68 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/120/status
/protocolSection/contactsLocationsModule/locations/127/status
/protocolSection/contactsLocationsModule/locations/148/facility
Triage: Critical
2023-05-26
Primary Outcome Change
v69 to v70 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/9/description
/protocolSection/armsInterventionsModule/armGroups/9/label
/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/0
Triage: High
2024-01-16
Enrollment Change
v76 to v77 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/centralContacts
/protocolSection/contactsLocationsModule/locations/0/status
/protocolSection/contactsLocationsModule/locations/1/status
Triage: Medium
2025-03-11
Timeline Shift
v88 to v89 Late Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/11/zip
/protocolSection/contactsLocationsModule/locations/46/city
/protocolSection/contactsLocationsModule/locations/46/geoPoint
Triage: Low
2025-05-12
Timeline Minor Adjustment
v90 to v91 Late Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/18
/protocolSection/contactsLocationsModule/locations/20
/protocolSection/contactsLocationsModule/locations/6/facility
Triage: Medium
2025-07-31
Timeline Significant Shift
v92 to v93 Late Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/1/facility
/protocolSection/contactsLocationsModule/locations/38/facility
/protocolSection/contactsLocationsModule/locations/4/facility
Triage: Low
2025-11-11
Timeline Actualized Earlier
v94 to v95 Late Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/16/facility
/protocolSection/contactsLocationsModule/locations/16/zip
/protocolSection/contactsLocationsModule/locations/80/facility