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NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 33 to 34 · Bayer

Patch inspector

Version 33 to 34

5 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
enrollment_count_change
Value signals
[
  {
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "signal": "enrollment_count_change_ge_20pct",
    "category": "enrollment_change",
    "severity": "high",
    "new_value": 203,
    "old_value": 120,
    "pct_change": 0.6917
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:21+00
Raw hash
73b62bf9b10bcb9d4796779136b6cea68018c33b128656beb2cd11a19603cd1e
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 3
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
120
After
203
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 2 ops
add /protocolSection/contactsLocationsModule/locations/21
Triage: Uncategorized
Uncategorized Operation 4
After
{
  "zip": "2065",
  "city": "St Leonards",
  "state": "New South Wales",
  "status": "NOT_YET_RECRUITING",
  "country": "Australia",
  "facility": "Royal North Shore Hospital",
  "geoPoint": {
    "lat": -33.82344,
    "lon": 151.19836
  }
}
add /protocolSection/contactsLocationsModule/locations/22
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "6009",
  "city": "Nedlands",
  "status": "NOT_YET_RECRUITING",
  "country": "Australia",
  "facility": "Sir Charles Gairdner Hospital",
  "geoPoint": {
    "lat": -31.98184,
    "lon": 115.8073
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-02-05
After
2020-03-02
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2020-02-06
After
2020-03-03
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-03-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-03-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 203
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/21",
    "value": {
      "zip": "2065",
      "city": "St Leonards",
      "state": "New South Wales",
      "status": "NOT_YET_RECRUITING",
      "country": "Australia",
      "facility": "Royal North Shore Hospital",
      "geoPoint": {
        "lat": -33.82344,
        "lon": 151.19836
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/22",
    "value": {
      "zip": "6009",
      "city": "Nedlands",
      "status": "NOT_YET_RECRUITING",
      "country": "Australia",
      "facility": "Sir Charles Gairdner Hospital",
      "geoPoint": {
        "lat": -31.98184,
        "lon": 115.8073
      }
    }
  }
]