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NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 35 to 36 · Bayer

Patch inspector

Version 35 to 36

28 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_earlier_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "earlier",
    "new_value": "2023-08-15",
    "old_value": "2025-09-30",
    "delta_days": 777,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:21+00
Raw hash
3d5e3c76a2514e5e04308378fa48774053dc86984dc883d955891811a578258d
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2025-09-30
After
2023-08-15
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 24 ops
add /protocolSection/contactsLocationsModule/locations/22
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "4029",
  "city": "Brisbane",
  "state": "Queensland",
  "status": "NOT_YET_RECRUITING",
  "country": "Australia",
  "facility": "Royal Brisbane & Women's Hospital",
  "geoPoint": {
    "lat": -27.46794,
    "lon": 153.02809
  }
}
add /protocolSection/contactsLocationsModule/locations/25
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "90470 340",
  "city": "Porto Alegre",
  "state": "Rio Grande do Sul",
  "status": "NOT_YET_RECRUITING",
  "country": "Brazil",
  "facility": "Irmandade Santa Casa de Misericordia de Porto Alegre",
  "geoPoint": {
    "lat": -30.03283,
    "lon": -51.23019
  }
}
add /protocolSection/contactsLocationsModule/locations/26
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "city": "São José do Rio Preto",
  "state": "São Paulo",
  "status": "NOT_YET_RECRUITING",
  "country": "Brazil",
  "facility": "Hospital de Base da Fundação F M S J Rio Preto",
  "geoPoint": {
    "lat": -20.81972,
    "lon": -49.37944
  }
}
replace /protocolSection/contactsLocationsModule/locations/29/status
Triage: Uncategorized
Uncategorized Operation 8
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/36
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "83100",
  "city": "Avellino",
  "state": "Campania",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "facility": "A.O. San Giuseppe Moscati",
  "geoPoint": {
    "lat": 40.91494,
    "lon": 14.79103
  }
}
add /protocolSection/contactsLocationsModule/locations/37
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "40138",
  "city": "Bologna",
  "state": "Emilia-Romagna",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "facility": "A.O.U. di Bologna Policlinico S.Orsola Malpighi",
  "geoPoint": {
    "lat": 44.49381,
    "lon": 11.33875
  }
}
add /protocolSection/contactsLocationsModule/locations/38
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "zip": "33100",
  "city": "Udine",
  "state": "Friuli Venezia Giulia",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "facility": "A.S.U. Friuli Centrale",
  "geoPoint": {
    "lat": 46.0693,
    "lon": 13.23715
  }
}
add /protocolSection/contactsLocationsModule/locations/39
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "00168",
  "city": "Rome",
  "state": "Lazio",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "facility": "Fondazione Policlinico Universitario Agostino Gemelli IRCCS",
  "geoPoint": {
    "lat": 41.89193,
    "lon": 12.51133
  }
}
add /protocolSection/contactsLocationsModule/locations/40
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "24127",
  "city": "Bergamo",
  "state": "Lombardy",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "facility": "ASST Papa Giovanni XXIII",
  "geoPoint": {
    "lat": 45.69601,
    "lon": 9.66721
  }
}
add /protocolSection/contactsLocationsModule/locations/41
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "20089",
  "city": "Milan",
  "state": "Lombardy",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "facility": "IRCCS Istituto Clinico Humanitas (ICH)",
  "geoPoint": {
    "lat": 45.46427,
    "lon": 9.18951
  }
}
add /protocolSection/contactsLocationsModule/locations/42
Triage: Uncategorized
Uncategorized Operation 15
After
{
  "zip": "20141",
  "city": "Milan",
  "state": "Lombardy",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "facility": "IRCCS Istituto Europeo di Oncologia (IEO)",
  "geoPoint": {
    "lat": 45.46427,
    "lon": 9.18951
  }
}
add /protocolSection/contactsLocationsModule/locations/43
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "zip": "35128",
  "city": "Padova",
  "state": "Veneto",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "facility": "IRCCS Istituto Oncologico Veneto (IOV)",
  "geoPoint": {
    "lat": 45.26618,
    "lon": 11.77208
  }
}
add /protocolSection/contactsLocationsModule/locations/50
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "163045",
  "city": "Arkhangelsk",
  "status": "NOT_YET_RECRUITING",
  "country": "Russia",
  "facility": "Arkhangelsk Clinical Oncology Dispensary",
  "geoPoint": {
    "lat": 64.5461,
    "lon": 40.55183
  }
}
add /protocolSection/contactsLocationsModule/locations/51
Triage: Uncategorized
Uncategorized Operation 18
After
{
  "zip": "454048",
  "city": "Chelyabinsk",
  "status": "NOT_YET_RECRUITING",
  "country": "Russia",
  "facility": "Ltd "EVIMED"",
  "geoPoint": {
    "lat": 55.1611,
    "lon": 61.42877
  }
}
add /protocolSection/contactsLocationsModule/locations/52
Triage: Uncategorized
Uncategorized Operation 19
After
{
  "zip": "111123",
  "city": "Moscow",
  "status": "NOT_YET_RECRUITING",
  "country": "Russia",
  "facility": "Moscow Clinical Scientific Centre n.a.Loginov",
  "geoPoint": {
    "lat": 55.75204,
    "lon": 37.61781
  }
}
add /protocolSection/contactsLocationsModule/locations/53
Triage: Uncategorized
Uncategorized Operation 20
After
{
  "zip": "115478",
  "city": "Moscow",
  "status": "NOT_YET_RECRUITING",
  "country": "Russia",
  "facility": "Russian Oncological Scientific Center n.a. N.N. Blokhin RAMS",
  "geoPoint": {
    "lat": 55.75204,
    "lon": 37.61781
  }
}
add /protocolSection/contactsLocationsModule/locations/54
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "119991",
  "city": "Moscow",
  "status": "NOT_YET_RECRUITING",
  "country": "Russia",
  "facility": "1st Moscow State Medical University n.a. I.M.Sechenov",
  "geoPoint": {
    "lat": 55.75204,
    "lon": 37.61781
  }
}
add /protocolSection/contactsLocationsModule/locations/55
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "zip": "125284",
  "city": "Moscow",
  "status": "NOT_YET_RECRUITING",
  "country": "Russia",
  "facility": "Moscow Scient. Res. Institute of Oncology n.a P.A. Hertzen",
  "geoPoint": {
    "lat": 55.75204,
    "lon": 37.61781
  }
}
add /protocolSection/contactsLocationsModule/locations/56
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "zip": "143423",
  "city": "Moscow",
  "status": "NOT_YET_RECRUITING",
  "country": "Russia",
  "facility": "City Oncological Hospital #62",
  "geoPoint": {
    "lat": 55.75204,
    "lon": 37.61781
  }
}
add /protocolSection/contactsLocationsModule/locations/57
Triage: Uncategorized
Uncategorized Operation 24
After
{
  "zip": "603006",
  "city": "Nizhny Novgorod",
  "status": "NOT_YET_RECRUITING",
  "country": "Russia",
  "facility": "FBHI Volga Regional Medical Center of Fed biomed agency",
  "geoPoint": {
    "lat": 56.32867,
    "lon": 44.00205
  }
}
add /protocolSection/contactsLocationsModule/locations/59
Triage: Uncategorized
Uncategorized Operation 25
After
{
  "zip": "812 50",
  "city": "Bratislava",
  "status": "NOT_YET_RECRUITING",
  "country": "Slovakia",
  "facility": "Onkologicky Ustav Svatej Alzbety, s.r.o.",
  "geoPoint": {
    "lat": 48.14816,
    "lon": 17.10674
  }
}
add /protocolSection/contactsLocationsModule/locations/60
Triage: Uncategorized
Uncategorized Operation 26
After
{
  "zip": "833 10",
  "city": "Bratislava",
  "status": "NOT_YET_RECRUITING",
  "country": "Slovakia",
  "facility": "Narodny onkologicky ustav",
  "geoPoint": {
    "lat": 48.14816,
    "lon": 17.10674
  }
}
add /protocolSection/contactsLocationsModule/locations/65
Triage: Uncategorized
Uncategorized Operation 27
After
{
  "zip": "136-705",
  "city": "Seoul",
  "status": "NOT_YET_RECRUITING",
  "country": "South Korea",
  "facility": "Korea University Anam Hospital",
  "geoPoint": {
    "lat": 37.566,
    "lon": 126.9784
  }
}
add /protocolSection/contactsLocationsModule/locations/73
Triage: Uncategorized
Uncategorized Operation 28
After
{
  "zip": "46010",
  "city": "Valencia",
  "status": "NOT_YET_RECRUITING",
  "country": "Spain",
  "facility": "Hospital Clínico Universitario de Valencia",
  "geoPoint": {
    "lat": 39.47391,
    "lon": -0.37966
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-03
After
2020-06
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2020-03-30
After
2020-06-03
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2020-04-01
After
2020-06-04
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2023-08-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-06-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-06-04"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/22",
    "value": {
      "zip": "4029",
      "city": "Brisbane",
      "state": "Queensland",
      "status": "NOT_YET_RECRUITING",
      "country": "Australia",
      "facility": "Royal Brisbane & Women's Hospital",
      "geoPoint": {
        "lat": -27.46794,
        "lon": 153.02809
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/25",
    "value": {
      "zip": "90470 340",
      "city": "Porto Alegre",
      "state": "Rio Grande do Sul",
      "status": "NOT_YET_RECRUITING",
      "country": "Brazil",
      "facility": "Irmandade Santa Casa de Misericordia de Porto Alegre",
      "geoPoint": {
        "lat": -30.03283,
        "lon": -51.23019
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/26",
    "value": {
      "city": "São José do Rio Preto",
      "state": "São Paulo",
      "status": "NOT_YET_RECRUITING",
      "country": "Brazil",
      "facility": "Hospital de Base da Fundação F M S J Rio Preto",
      "geoPoint": {
        "lat": -20.81972,
        "lon": -49.37944
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/29/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/36",
    "value": {
      "zip": "83100",
      "city": "Avellino",
      "state": "Campania",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "facility": "A.O. San Giuseppe Moscati",
      "geoPoint": {
        "lat": 40.91494,
        "lon": 14.79103
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/37",
    "value": {
      "zip": "40138",
      "city": "Bologna",
      "state": "Emilia-Romagna",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "facility": "A.O.U. di Bologna Policlinico S.Orsola Malpighi",
      "geoPoint": {
        "lat": 44.49381,
        "lon": 11.33875
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/38",
    "value": {
      "zip": "33100",
      "city": "Udine",
      "state": "Friuli Venezia Giulia",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "facility": "A.S.U. Friuli Centrale",
      "geoPoint": {
        "lat": 46.0693,
        "lon": 13.23715
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/39",
    "value": {
      "zip": "00168",
      "city": "Rome",
      "state": "Lazio",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "facility": "Fondazione Policlinico Universitario Agostino Gemelli IRCCS",
      "geoPoint": {
        "lat": 41.89193,
        "lon": 12.51133
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/40",
    "value": {
      "zip": "24127",
      "city": "Bergamo",
      "state": "Lombardy",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "facility": "ASST Papa Giovanni XXIII",
      "geoPoint": {
        "lat": 45.69601,
        "lon": 9.66721
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/41",
    "value": {
      "zip": "20089",
      "city": "Milan",
      "state": "Lombardy",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "facility": "IRCCS Istituto Clinico Humanitas (ICH)",
      "geoPoint": {
        "lat": 45.46427,
        "lon": 9.18951
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/42",
    "value": {
      "zip": "20141",
      "city": "Milan",
      "state": "Lombardy",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "facility": "IRCCS Istituto Europeo di Oncologia (IEO)",
      "geoPoint": {
        "lat": 45.46427,
        "lon": 9.18951
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/43",
    "value": {
      "zip": "35128",
      "city": "Padova",
      "state": "Veneto",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "facility": "IRCCS Istituto Oncologico Veneto (IOV)",
      "geoPoint": {
        "lat": 45.26618,
        "lon": 11.77208
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/50",
    "value": {
      "zip": "163045",
      "city": "Arkhangelsk",
      "status": "NOT_YET_RECRUITING",
      "country": "Russia",
      "facility": "Arkhangelsk Clinical Oncology Dispensary",
      "geoPoint": {
        "lat": 64.5461,
        "lon": 40.55183
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/51",
    "value": {
      "zip": "454048",
      "city": "Chelyabinsk",
      "status": "NOT_YET_RECRUITING",
      "country": "Russia",
      "facility": "Ltd "EVIMED"",
      "geoPoint": {
        "lat": 55.1611,
        "lon": 61.42877
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/52",
    "value": {
      "zip": "111123",
      "city": "Moscow",
      "status": "NOT_YET_RECRUITING",
      "country": "Russia",
      "facility": "Moscow Clinical Scientific Centre n.a.Loginov",
      "geoPoint": {
        "lat": 55.75204,
        "lon": 37.61781
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/53",
    "value": {
      "zip": "115478",
      "city": "Moscow",
      "status": "NOT_YET_RECRUITING",
      "country": "Russia",
      "facility": "Russian Oncological Scientific Center n.a. N.N. Blokhin RAMS",
      "geoPoint": {
        "lat": 55.75204,
        "lon": 37.61781
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/54",
    "value": {
      "zip": "119991",
      "city": "Moscow",
      "status": "NOT_YET_RECRUITING",
      "country": "Russia",
      "facility": "1st Moscow State Medical University n.a. I.M.Sechenov",
      "geoPoint": {
        "lat": 55.75204,
        "lon": 37.61781
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/55",
    "value": {
      "zip": "125284",
      "city": "Moscow",
      "status": "NOT_YET_RECRUITING",
      "country": "Russia",
      "facility": "Moscow Scient. Res. Institute of Oncology n.a P.A. Hertzen",
      "geoPoint": {
        "lat": 55.75204,
        "lon": 37.61781
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/56",
    "value": {
      "zip": "143423",
      "city": "Moscow",
      "status": "NOT_YET_RECRUITING",
      "country": "Russia",
      "facility": "City Oncological Hospital #62",
      "geoPoint": {
        "lat": 55.75204,
        "lon": 37.61781
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/57",
    "value": {
      "zip": "603006",
      "city": "Nizhny Novgorod",
      "status": "NOT_YET_RECRUITING",
      "country": "Russia",
      "facility": "FBHI Volga Regional Medical Center of Fed biomed agency",
      "geoPoint": {
        "lat": 56.32867,
        "lon": 44.00205
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/59",
    "value": {
      "zip": "812 50",
      "city": "Bratislava",
      "status": "NOT_YET_RECRUITING",
      "country": "Slovakia",
      "facility": "Onkologicky Ustav Svatej Alzbety, s.r.o.",
      "geoPoint": {
        "lat": 48.14816,
        "lon": 17.10674
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/60",
    "value": {
      "zip": "833 10",
      "city": "Bratislava",
      "status": "NOT_YET_RECRUITING",
      "country": "Slovakia",
      "facility": "Narodny onkologicky ustav",
      "geoPoint": {
        "lat": 48.14816,
        "lon": 17.10674
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/65",
    "value": {
      "zip": "136-705",
      "city": "Seoul",
      "status": "NOT_YET_RECRUITING",
      "country": "South Korea",
      "facility": "Korea University Anam Hospital",
      "geoPoint": {
        "lat": 37.566,
        "lon": 126.9784
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/73",
    "value": {
      "zip": "46010",
      "city": "Valencia",
      "status": "NOT_YET_RECRUITING",
      "country": "Spain",
      "facility": "Hospital Clínico Universitario de Valencia",
      "geoPoint": {
        "lat": 39.47391,
        "lon": -0.37966
      }
    }
  }
]