Back to trial

NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 36 to 37 · Bayer

Patch inspector

Version 36 to 37

7 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
secondary_outcome_any_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:22+00
Raw hash
e5de070f9dde59905538710b09c9b20897b19069002765425cbad156131c165e
Payload
Source URL
Secondary outcomes Additional endpoints and outcome descriptions. Triage: High 1 ops
replace /protocolSection/outcomesModule/secondaryOutcomes/19/description
Triage: High
Secondary Outcome Change Operation 4
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
Before
Describes the concordance of prior molecular profiling that detected an NTRK fusion within the subject's tumor and a diagnostic test being evaluated by the sponsor.
After
Describes the concordance of prior molecular profiling that detected an NTRK fusion within the subject's tumor and a diagnostic test being evaluated by the sponsor
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 3 ops
replace /protocolSection/contactsLocationsModule/locations/22/status
Triage: Uncategorized
Uncategorized Operation 5
Before
NOT_YET_RECRUITING
After
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/44/status
Triage: Uncategorized
Uncategorized Operation 6
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/46/status
Triage: Uncategorized
Uncategorized Operation 7
Before
NOT_YET_RECRUITING
After
RECRUITING
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-06
After
2020-07
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2020-06-03
After
2020-07-02
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2020-06-04
After
2020-07-07
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-07-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-07-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/19/description",
    "value": "Describes the concordance of prior molecular profiling that detected an NTRK fusion within the subject's tumor and a diagnostic test being evaluated by the sponsor"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/22/status",
    "value": "WITHDRAWN"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/44/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/46/status",
    "value": "RECRUITING"
  }
]