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NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 67 to 68 · Bayer

Patch inspector

Version 67 to 68

8 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2025-07-20",
    "old_value": "2023-08-15",
    "delta_days": 705,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2025-10-31",
    "old_value": "2025-08-29",
    "delta_days": 63,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:31+00
Raw hash
532f81a2ca60967a0fe6cc32300e89b3743a3bcfd9177272f66a27dbda4db585
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 1
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2023-08-15
After
2025-07-20
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2025-08-29
After
2025-10-31
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 4 ops
replace /protocolSection/contactsLocationsModule/locations/120/status
Triage: Uncategorized
Uncategorized Operation 5
Before
RECRUITING
After
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/127/status
Triage: Uncategorized
Uncategorized Operation 6
Before
RECRUITING
After
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/148/facility
Triage: Uncategorized
Uncategorized Operation 7
Before
Ankara Sehir Hastanesi
After
Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital
replace /protocolSection/contactsLocationsModule/locations/148/zip
Triage: Uncategorized
Uncategorized Operation 8
Before
06800
After
6800
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2023-01-17
After
2023-02-17
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2023-01-18
After
2023-02-21
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2025-07-20"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2025-10-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2023-02-17"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2023-02-21"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/120/status",
    "value": "WITHDRAWN"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/127/status",
    "value": "WITHDRAWN"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/148/facility",
    "value": "Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/148/zip",
    "value": "6800"
  }
]