Back to trial

NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 88 to 89 · Bayer

Patch inspector

Version 88 to 89

9 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2025-11-30",
    "old_value": "2025-10-31",
    "delta_days": 30,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:36+00
Raw hash
0a908f1ce11eb139bf57ac7935eaba32be2bcb96df51a71da42b61fb74b211d9
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2025-10-31
After
2025-11-30
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 5 ops
replace /protocolSection/contactsLocationsModule/locations/11/zip
Triage: Uncategorized
Uncategorized Operation 5
Before
19111-2497
After
19111
replace /protocolSection/contactsLocationsModule/locations/46/city
Triage: Uncategorized
Uncategorized Operation 6
Before
Copenhagen
After
Copenhagen OE
remove /protocolSection/contactsLocationsModule/locations/46/geoPoint
Triage: Uncategorized
Uncategorized Operation 7
Before
{
  "lat": 55.67594,
  "lon": 12.56553
}
replace /protocolSection/contactsLocationsModule/locations/48/facility
Triage: Uncategorized
Uncategorized Operation 8
Before
Institut Bergonié - Unicancer Nouvelle Aquitaine - Service Oncologie médicale
After
Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale
replace /protocolSection/contactsLocationsModule/locations/82/zip
Triage: Uncategorized
Uncategorized Operation 9
Before
6351
After
06351
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2025-02
After
2025-03
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2025-02-07
After
2025-03-11
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2025-02-10
After
2025-03-12
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2025-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2025-11-30"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2025-03-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2025-03-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/11/zip",
    "value": "19111"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/46/city",
    "value": "Copenhagen OE"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/46/geoPoint"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/48/facility",
    "value": "Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/82/zip",
    "value": "06351"
  }
]