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NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 90 to 91 · Bayer

Patch inspector

Version 90 to 91

14 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_earlier_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2025-10-31",
    "old_value": "2025-11-30",
    "delta_days": 30,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:37+00
Raw hash
e46192fd5c6b4568f38a6b51d043ed2a6ded702a05d34ba2ed5f32fbc6d99cf3
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2025-11-30
After
2025-10-31
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 10 ops
replace /protocolSection/contactsLocationsModule/locations/6/facility
Triage: Uncategorized
Uncategorized Operation 5
Before
Memorial Sloan Kettering Cancer Center - New York
After
Memorial Sloan Kettering Cancer Center New York - Main Campus
replace /protocolSection/contactsLocationsModule/locations/6/zip
Triage: Uncategorized
Uncategorized Operation 6
Before
10021
After
10065
add /protocolSection/contactsLocationsModule/locations/18
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "C11118AAT",
  "city": "Buenos Aires",
  "state": "Ciudad Auton. de Buenos Aires",
  "country": "Argentina",
  "facility": "Hospital Alemán",
  "geoPoint": {
    "lat": -34.61315,
    "lon": -58.37723
  }
}
remove /protocolSection/contactsLocationsModule/locations/20
Triage: Uncategorized
Uncategorized Operation 8
Before
{
  "zip": "TBC",
  "city": "Buenos Aires",
  "state": "Ciudad Auton. de Buenos Aires",
  "country": "Argentina",
  "facility": "Hospital Alemán",
  "geoPoint": {
    "lat": -34.61315,
    "lon": -58.37723
  }
}
replace /protocolSection/contactsLocationsModule/locations/83/facility
Triage: Uncategorized
Uncategorized Operation 9
Before
Institut Català d'Oncologia Hospitalet
After
Institut Catala D'oncologia - Oncologia
replace /protocolSection/contactsLocationsModule/locations/83/city
Triage: Uncategorized
Uncategorized Operation 10
Before
L'Hospitalet de Llobregat
After
Barcelona
replace /protocolSection/contactsLocationsModule/locations/83/state
Triage: Uncategorized
Uncategorized Operation 11
Before
Barcelona
After
L Hospitalet de Llobregat
replace /protocolSection/contactsLocationsModule/locations/83/zip
Triage: Uncategorized
Uncategorized Operation 12
Before
08907
After
8907
replace /protocolSection/contactsLocationsModule/locations/83/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 13
Before
41.35967
After
41.38879
replace /protocolSection/contactsLocationsModule/locations/83/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 14
Before
2.10028
After
2.15899
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2025-04
After
2025-05
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2025-04-08
After
2025-05-12
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2025-04-09
After
2025-05-13
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2025-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2025-10-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2025-05-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2025-05-13"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/facility",
    "value": "Memorial Sloan Kettering Cancer Center New York - Main Campus"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/zip",
    "value": "10065"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/18",
    "value": {
      "zip": "C11118AAT",
      "city": "Buenos Aires",
      "state": "Ciudad Auton. de Buenos Aires",
      "country": "Argentina",
      "facility": "Hospital Alemán",
      "geoPoint": {
        "lat": -34.61315,
        "lon": -58.37723
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/20"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/83/facility",
    "value": "Institut Catala D'oncologia - Oncologia"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/83/city",
    "value": "Barcelona"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/83/state",
    "value": "L Hospitalet de Llobregat"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/83/zip",
    "value": "8907"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/83/geoPoint/lat",
    "value": 41.38879
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/83/geoPoint/lon",
    "value": 2.15899
  }
]