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NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 92 to 93 · Bayer

Patch inspector

Version 92 to 93

12 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2025-10-31",
    "old_value": "2025-07-20",
    "delta_days": 103,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:38+00
Raw hash
aa914c1cc06ea307d96bc8dd03b55546382808515f6aebe0798675fd701573aa
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2025-07-20
After
2025-10-31
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 8 ops
replace /protocolSection/contactsLocationsModule/locations/1/facility
Triage: Uncategorized
Uncategorized Operation 5
Before
UCLA-Santa Monica Medical Center
After
UCLA Health Santa Monica Cancer Care
replace /protocolSection/contactsLocationsModule/locations/4/facility
Triage: Uncategorized
Uncategorized Operation 6
Before
Massachusetts General Hospital
After
Mass General Cancer Center
replace /protocolSection/contactsLocationsModule/locations/5/facility
Triage: Uncategorized
Uncategorized Operation 7
Before
Dana-Farber Cancer Institute
After
Dana-Farber Cancer Institute - Oncology Department
replace /protocolSection/contactsLocationsModule/locations/38/facility
Triage: Uncategorized
Uncategorized Operation 8
Before
Beijing Cancer Hospital
After
Beijing Cancer Hospital - Oncology Department
replace /protocolSection/contactsLocationsModule/locations/41/facility
Triage: Uncategorized
Uncategorized Operation 9
Before
Zhongshan Hospital, Fudan University
After
Zhongshan Hospital, Fudan University - Oncology Department
replace /protocolSection/contactsLocationsModule/locations/76/facility
Triage: Uncategorized
Uncategorized Operation 10
Before
National Cancer Center Singapore
After
National Cancer Center Singapore - Oncology Department
replace /protocolSection/contactsLocationsModule/locations/80/facility
Triage: Uncategorized
Uncategorized Operation 11
Before
Asan Medical Center
After
Asan Medical Center - Oncology Department
replace /protocolSection/contactsLocationsModule/locations/82/facility
Triage: Uncategorized
Uncategorized Operation 12
Before
Samsung Medical Center
After
Samsung Medical Center - Oncology Department
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2025-06
After
2025-07
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2025-06-26
After
2025-07-31
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2025-06-27
After
2025-08-01
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2025-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2025-10-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2025-07-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2025-08-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/facility",
    "value": "UCLA Health Santa Monica Cancer Care"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/facility",
    "value": "Mass General Cancer Center"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/facility",
    "value": "Dana-Farber Cancer Institute - Oncology Department"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/38/facility",
    "value": "Beijing Cancer Hospital - Oncology Department"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/41/facility",
    "value": "Zhongshan Hospital, Fudan University - Oncology Department"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/76/facility",
    "value": "National Cancer Center Singapore - Oncology Department"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/80/facility",
    "value": "Asan Medical Center - Oncology Department"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/82/facility",
    "value": "Samsung Medical Center - Oncology Department"
  }
]