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NCT02576431

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Version 94 to 95 · Bayer

Patch inspector

Version 94 to 95

12 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_actualized_earlier",
    "category": "timeline_actualized_earlier",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2025-09-29",
    "old_value": "2025-10-31",
    "delta_days": 32,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_actualized_earlier",
    "category": "timeline_actualized_earlier",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2025-09-29",
    "old_value": "2025-10-31",
    "delta_days": 32,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:39+00
Raw hash
6d96c19d534a45ca321cef62d73270125e3410e39f0163291adfde0af06fcf22
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 4 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2025-10-31
After
2025-09-29
replace /protocolSection/statusModule/primaryCompletionDateStruct/type
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 5
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2025-10-31
After
2025-09-29
replace /protocolSection/statusModule/completionDateStruct/type
Triage: Medium
Timeline Shift Operation 6
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 4 ops
replace /protocolSection/contactsLocationsModule/locations/16/facility
Triage: Uncategorized
Uncategorized Operation 9
Before
University of Washington
After
Fred Hutch Cancer Center - Sloan Clinic 1
replace /protocolSection/contactsLocationsModule/locations/16/zip
Triage: Uncategorized
Uncategorized Operation 10
Before
0
After
98109
replace /protocolSection/contactsLocationsModule/locations/80/facility
Triage: Uncategorized
Uncategorized Operation 11
Before
Asan Medical Center - Oncology Department
After
Asan Medical Center-Ophthalmology
replace /protocolSection/contactsLocationsModule/locations/87/facility
Triage: Uncategorized
Uncategorized Operation 12
Before
Fundacion Jimenez Diaz (Clinica de la Concepcion)
After
Hospital Universitario Fundacion Jimenez Diaz
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2025-08
After
2025-11
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 7
Before
2025-08-29
After
2025-11-11
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 8
Before
2025-09-02
After
2025-11-12
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
ACTIVE_NOT_RECRUITING
After
COMPLETED
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2025-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2025-09-29"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2025-09-29"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2025-11-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2025-11-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/16/facility",
    "value": "Fred Hutch Cancer Center - Sloan Clinic 1"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/16/zip",
    "value": "98109"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/80/facility",
    "value": "Asan Medical Center-Ophthalmology"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/87/facility",
    "value": "Hospital Universitario Fundacion Jimenez Diaz"
  }
]