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NCT04224272

A Study of ZW25 (Zanidatamab) With Palbociclib Plus Fulvestrant in Patients With HER2+/HR+ Advanced Breast Cancer

Version 0 to 1 · Jazz Pharmaceuticals

Patch inspector

Version 0 to 1

5 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2020-04",
    "old_value": "2020-01",
    "delta_days": 91,
    "date_struct": "startDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:05+00
Raw hash
af2d2fc25396320ec146788de38b1699d97df67d02e9f42584cbaebb975ff0ae
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2020-01
After
2020-04
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 1 ops
add /protocolSection/contactsLocationsModule/locations/0
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "37203",
  "city": "Nashville",
  "state": "Tennessee",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Erika Hamilton, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Sarah Cannon Research Institute",
  "geoPoint": {
    "lat": 36.16589,
    "lon": -86.78444
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-01
After
2020-03
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2020-01-08
After
2020-03-30
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2020-01-13
After
2020-03-31
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2020-04"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-03-30"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-03-31"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0",
    "value": {
      "zip": "37203",
      "city": "Nashville",
      "state": "Tennessee",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Erika Hamilton, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Sarah Cannon Research Institute",
      "geoPoint": {
        "lat": 36.16589,
        "lon": -86.78444
      }
    }
  }
]