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NCT04224272

A Study of ZW25 (Zanidatamab) With Palbociclib Plus Fulvestrant in Patients With HER2+/HR+ Advanced Breast Cancer

Phase 2a Study of ZW25 in Combination With Palbociclib Plus Fulvestrant

ClinicalTrials.gov
Sponsor
Jazz Pharmaceuticals
Status
Completed
Versions
21
Adjacent patches
20
Severity is deterministic, reproducible, uncalibrated triage metadata, not validated review priority or proven wrongdoing. New Evidence Record packages are generated for deterministic event-class membership, not by triage rank alone.

Material event timeline

11 shown
Triage: Medium
2020-03-30
Timeline Significant Shift
v0 to v1 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/0
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate
Triage: Medium
2020-06-18
Timeline Shift
v1 to v2 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/2
/protocolSection/contactsLocationsModule/locations/3
/protocolSection/contactsLocationsModule/locations/4
Triage: Critical
2020-08-04
Primary Outcome Change
v2 to v3 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/0/description
/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0
/protocolSection/armsInterventionsModule/armGroups/0/label
Triage: High
2020-08-27
Design Change
v3 to v4 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/0
/protocolSection/contactsLocationsModule/locations/3
/protocolSection/designModule/designInfo/allocation
Triage: Medium
2022-04-29
Timeline Significant Shift
v10 to v11 Early Recruitment Inspect patch
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate
/protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Low
2022-11-17
Administrative Contact Change
v12 to v13 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/centralContacts
/protocolSection/contactsLocationsModule/locations/0/contacts
/protocolSection/contactsLocationsModule/locations/0/status
Triage: High
2023-08-11
Enrollment Change
v13 to v14 Late Recruitment Inspect patch
/protocolSection/contactsLocationsModule/overallOfficials
/protocolSection/designModule/enrollmentInfo/count
/protocolSection/designModule/enrollmentInfo/type
Triage: Low
2024-04-26
Results Reconciliation
v16 to v17 Late Recruitment Inspect patch Evidence Record
/annotationSection
/documentSection
/hasResults
Triage: Low
2024-08-13
Results Reconciliation
v17 to v18 Late Recruitment Inspect patch Evidence Record
/annotationSection
/protocolSection/outcomesModule/primaryOutcomes/2/description
/protocolSection/outcomesModule/primaryOutcomes/2/reviewUnit
Triage: Low
2025-05-20
Timeline Minor Adjustment
v18 to v19 Late Recruitment Inspect patch
/protocolSection/statusModule/completionDateStruct/date
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate
Triage: Low
2025-07-22
Milestone Realized
v19 to v20 Late Recruitment Inspect patch
/protocolSection/statusModule/completionDateStruct/type
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate