Back to trial

NCT04224272

A Study of ZW25 (Zanidatamab) With Palbociclib Plus Fulvestrant in Patients With HER2+/HR+ Advanced Breast Cancer

Version 1 to 2 · Jazz Pharmaceuticals

Patch inspector

Version 1 to 2

9 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2020-06-10",
    "old_value": "2020-04",
    "delta_days": 70,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:05+00
Raw hash
3cfdcc2b4c4c77d148afb5f4587c3a4fda48a0c7d275305aa789304f18cefd10
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2020-04
After
2020-06-10
replace /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 3 ops
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "08035",
  "city": "Barcelona",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "Santiago Escrivá de Romaní Muñoz, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Hospital Universitario Vall d'Hebrón",
  "geoPoint": {
    "lat": 41.38879,
    "lon": 2.15899
  }
}
add /protocolSection/contactsLocationsModule/locations/3
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "28034",
  "city": "Madrid",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "Javier Cortés Castan, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Hospital Ruber Internacional",
  "geoPoint": {
    "lat": 40.4165,
    "lon": -3.70256
  }
}
add /protocolSection/contactsLocationsModule/locations/4
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "46010",
  "city": "Valencia",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "Juan Miguel Cejalvo Andújar, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Hospital Clínico Universitario de Valencia",
  "geoPoint": {
    "lat": 39.47391,
    "lon": -0.37966
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-03
After
2020-06
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2020-03-30
After
2020-06-18
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2020-03-31
After
2020-06-22
add /protocolSection/ipdSharingStatementModule
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "ipdSharing": "NO"
}
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2020-06-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-06-18"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-06-22"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "zip": "08035",
      "city": "Barcelona",
      "status": "RECRUITING",
      "country": "Spain",
      "contacts": [
        {
          "name": "Santiago Escrivá de Romaní Muñoz, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Hospital Universitario Vall d'Hebrón",
      "geoPoint": {
        "lat": 41.38879,
        "lon": 2.15899
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3",
    "value": {
      "zip": "28034",
      "city": "Madrid",
      "status": "RECRUITING",
      "country": "Spain",
      "contacts": [
        {
          "name": "Javier Cortés Castan, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Hospital Ruber Internacional",
      "geoPoint": {
        "lat": 40.4165,
        "lon": -3.70256
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/4",
    "value": {
      "zip": "46010",
      "city": "Valencia",
      "status": "RECRUITING",
      "country": "Spain",
      "contacts": [
        {
          "name": "Juan Miguel Cejalvo Andújar, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Hospital Clínico Universitario de Valencia",
      "geoPoint": {
        "lat": 39.47391,
        "lon": -0.37966
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/ipdSharingStatementModule",
    "value": {
      "ipdSharing": "NO"
    }
  }
]