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NCT04224272

A Study of ZW25 (Zanidatamab) With Palbociclib Plus Fulvestrant in Patients With HER2+/HR+ Advanced Breast Cancer

Version 12 to 13 · Jazz Pharmaceuticals

Patch inspector

Version 12 to 13

94 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:07+00
Raw hash
4a51b7f8cfea61ed333621e16c34a292b4025b530a3c2e49991d6baeec56b220
Payload
Source URL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 90 ops
remove /protocolSection/contactsLocationsModule/centralContacts
Triage: Low
Administrative Contact Change Operation 5
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
[
  {
    "name": "Zymeworks Clinical Trial Resource",
    "role": "CONTACT",
    "email": "medinfo@zymeworks.com",
    "phone": "(206) 237-1030"
  }
]
remove /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 6
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/0/contacts
Triage: Uncategorized
Uncategorized Operation 7
Before
[
  {
    "name": "Sara Hurvitz, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
remove /protocolSection/contactsLocationsModule/locations/1/status
Triage: Uncategorized
Uncategorized Operation 8
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1/contacts
Triage: Uncategorized
Uncategorized Operation 9
Before
[
  {
    "name": "Erika Hamilton, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/2/facility
Triage: Uncategorized
Uncategorized Operation 10
Before
South Texas Accelerated Research Therapeutics
After
Seattle Cancer Care Alliance
remove /protocolSection/contactsLocationsModule/locations/2/status
Triage: Uncategorized
Uncategorized Operation 11
Before
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/2/city
Triage: Uncategorized
Uncategorized Operation 12
Before
San Antonio
After
Seattle
replace /protocolSection/contactsLocationsModule/locations/2/state
Triage: Uncategorized
Uncategorized Operation 13
Before
Texas
After
Washington
replace /protocolSection/contactsLocationsModule/locations/2/zip
Triage: Uncategorized
Uncategorized Operation 14
Before
78229
After
98109
replace /protocolSection/contactsLocationsModule/locations/2/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 15
Before
29.42412
After
47.60621
replace /protocolSection/contactsLocationsModule/locations/2/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 16
Before
-98.49363
After
-122.33207
replace /protocolSection/contactsLocationsModule/locations/3/facility
Triage: Uncategorized
Uncategorized Operation 17
Before
Seattle Cancer Care Alliance
After
Tom Baker Cancer Centre
remove /protocolSection/contactsLocationsModule/locations/3/status
Triage: Uncategorized
Uncategorized Operation 18
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/3/city
Triage: Uncategorized
Uncategorized Operation 19
Before
Seattle
After
Calgary
replace /protocolSection/contactsLocationsModule/locations/3/state
Triage: Uncategorized
Uncategorized Operation 20
Before
Washington
After
Alberta
replace /protocolSection/contactsLocationsModule/locations/3/zip
Triage: Uncategorized
Uncategorized Operation 21
Before
98109
After
T2N4N2
replace /protocolSection/contactsLocationsModule/locations/3/country
Triage: Uncategorized
Uncategorized Operation 22
Before
United States
After
Canada
remove /protocolSection/contactsLocationsModule/locations/3/contacts
Triage: Uncategorized
Uncategorized Operation 23
Before
[
  {
    "name": "Hannah Linden, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/3/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 24
Before
47.60621
After
51.05011
replace /protocolSection/contactsLocationsModule/locations/3/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 25
Before
-122.33207
After
-114.08529
replace /protocolSection/contactsLocationsModule/locations/4/facility
Triage: Uncategorized
Uncategorized Operation 26
Before
Tom Baker Cancer Centre
After
The Ottawa Hospital Cancer Centre
remove /protocolSection/contactsLocationsModule/locations/4/status
Triage: Uncategorized
Uncategorized Operation 27
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/4/city
Triage: Uncategorized
Uncategorized Operation 28
Before
Calgary
After
Ottawa
replace /protocolSection/contactsLocationsModule/locations/4/state
Triage: Uncategorized
Uncategorized Operation 29
Before
Alberta
After
Ontario
replace /protocolSection/contactsLocationsModule/locations/4/zip
Triage: Uncategorized
Uncategorized Operation 30
Before
T2N4N2
After
K1H 8L6
remove /protocolSection/contactsLocationsModule/locations/4/contacts
Triage: Uncategorized
Uncategorized Operation 31
Before
[
  {
    "name": "Marc Webster, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/4/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 32
Before
51.05011
After
45.41117
replace /protocolSection/contactsLocationsModule/locations/4/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 33
Before
-114.08529
After
-75.69812
replace /protocolSection/contactsLocationsModule/locations/5/facility
Triage: Uncategorized
Uncategorized Operation 34
Before
The Ottawa Hospital Cancer Centre
After
Sunnybrook Research Institute
remove /protocolSection/contactsLocationsModule/locations/5/status
Triage: Uncategorized
Uncategorized Operation 35
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/5/city
Triage: Uncategorized
Uncategorized Operation 36
Before
Ottawa
After
Toronto
replace /protocolSection/contactsLocationsModule/locations/5/zip
Triage: Uncategorized
Uncategorized Operation 37
Before
K1H 8L6
After
M4N3M5
remove /protocolSection/contactsLocationsModule/locations/5/contacts
Triage: Uncategorized
Uncategorized Operation 38
Before
[
  {
    "name": "Marie-France Savard, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/5/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 39
Before
45.41117
After
43.70643
replace /protocolSection/contactsLocationsModule/locations/5/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 40
Before
-75.69812
After
-79.39864
replace /protocolSection/contactsLocationsModule/locations/6/facility
Triage: Uncategorized
Uncategorized Operation 41
Before
Sunnybrook Research Institute
After
Jewish General Hospital
remove /protocolSection/contactsLocationsModule/locations/6/status
Triage: Uncategorized
Uncategorized Operation 42
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/6/city
Triage: Uncategorized
Uncategorized Operation 43
Before
Toronto
After
Montreal
replace /protocolSection/contactsLocationsModule/locations/6/state
Triage: Uncategorized
Uncategorized Operation 44
Before
Ontario
After
Quebec
replace /protocolSection/contactsLocationsModule/locations/6/zip
Triage: Uncategorized
Uncategorized Operation 45
Before
M4N3M5
After
H3T1E2
remove /protocolSection/contactsLocationsModule/locations/6/contacts
Triage: Uncategorized
Uncategorized Operation 46
Before
[
  {
    "name": "Rossanna Pezo, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/6/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 47
Before
43.70643
After
45.50884
replace /protocolSection/contactsLocationsModule/locations/6/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 48
Before
-79.39864
After
-73.58781
replace /protocolSection/contactsLocationsModule/locations/7/facility
Triage: Uncategorized
Uncategorized Operation 49
Before
Jewish General Hospital
After
Hospital General Universitario de Elche
remove /protocolSection/contactsLocationsModule/locations/7/status
Triage: Uncategorized
Uncategorized Operation 50
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/7/city
Triage: Uncategorized
Uncategorized Operation 51
Before
Montreal
After
Elche
replace /protocolSection/contactsLocationsModule/locations/7/state
Triage: Uncategorized
Uncategorized Operation 52
Before
Quebec
After
Alicante
replace /protocolSection/contactsLocationsModule/locations/7/zip
Triage: Uncategorized
Uncategorized Operation 53
Before
H3T1E2
After
03203
replace /protocolSection/contactsLocationsModule/locations/7/country
Triage: Uncategorized
Uncategorized Operation 54
Before
Canada
After
Spain
remove /protocolSection/contactsLocationsModule/locations/7/contacts
Triage: Uncategorized
Uncategorized Operation 55
Before
[
  {
    "name": "Cristiano Ferrario, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/7/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 56
Before
45.50884
After
38.26218
replace /protocolSection/contactsLocationsModule/locations/7/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 57
Before
-73.58781
After
-0.70107
replace /protocolSection/contactsLocationsModule/locations/8/facility
Triage: Uncategorized
Uncategorized Operation 58
Before
Hospital General Universitario de Elche
After
Hospital Universitario Vall d'Hebrón
remove /protocolSection/contactsLocationsModule/locations/8/status
Triage: Uncategorized
Uncategorized Operation 59
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/8/city
Triage: Uncategorized
Uncategorized Operation 60
Before
Elche
After
Barcelona
remove /protocolSection/contactsLocationsModule/locations/8/state
Triage: Uncategorized
Uncategorized Operation 61
Before
Alicante
replace /protocolSection/contactsLocationsModule/locations/8/zip
Triage: Uncategorized
Uncategorized Operation 62
Before
03203
After
08035
remove /protocolSection/contactsLocationsModule/locations/8/contacts
Triage: Uncategorized
Uncategorized Operation 63
Before
[
  {
    "name": "Álvaro Rodriguez-Lescure, MD, PhD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/8/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 64
Before
38.26218
After
41.38879
replace /protocolSection/contactsLocationsModule/locations/8/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 65
Before
-0.70107
After
2.15899
replace /protocolSection/contactsLocationsModule/locations/9/facility
Triage: Uncategorized
Uncategorized Operation 66
Before
Hospital Universitario Vall d'Hebrón
After
Hospital Ruber Internacional
remove /protocolSection/contactsLocationsModule/locations/9/status
Triage: Uncategorized
Uncategorized Operation 67
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/9/city
Triage: Uncategorized
Uncategorized Operation 68
Before
Barcelona
After
Madrid
replace /protocolSection/contactsLocationsModule/locations/9/zip
Triage: Uncategorized
Uncategorized Operation 69
Before
08035
After
28034
remove /protocolSection/contactsLocationsModule/locations/9/contacts
Triage: Uncategorized
Uncategorized Operation 70
Before
[
  {
    "name": "Santiago Escrivá de Romaní Muñoz, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/9/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 71
Before
41.38879
After
40.4165
replace /protocolSection/contactsLocationsModule/locations/9/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 72
Before
2.15899
After
-3.70256
replace /protocolSection/contactsLocationsModule/locations/10/facility
Triage: Uncategorized
Uncategorized Operation 73
Before
Hospital Ruber Internacional
After
Hospital Universitario Virgen de la Victoria
remove /protocolSection/contactsLocationsModule/locations/10/status
Triage: Uncategorized
Uncategorized Operation 74
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/10/city
Triage: Uncategorized
Uncategorized Operation 75
Before
Madrid
After
Málaga
replace /protocolSection/contactsLocationsModule/locations/10/zip
Triage: Uncategorized
Uncategorized Operation 76
Before
28034
After
29010
remove /protocolSection/contactsLocationsModule/locations/10/contacts
Triage: Uncategorized
Uncategorized Operation 77
Before
[
  {
    "name": "María Gion Cortés, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/10/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 78
Before
40.4165
After
36.72016
replace /protocolSection/contactsLocationsModule/locations/10/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 79
Before
-3.70256
After
-4.42034
replace /protocolSection/contactsLocationsModule/locations/11/facility
Triage: Uncategorized
Uncategorized Operation 80
Before
Hospital Universitario Virgen de la Victoria
After
Hospital Universitario Virgen del Rocío
remove /protocolSection/contactsLocationsModule/locations/11/status
Triage: Uncategorized
Uncategorized Operation 81
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/11/city
Triage: Uncategorized
Uncategorized Operation 82
Before
Málaga
After
Seville
replace /protocolSection/contactsLocationsModule/locations/11/zip
Triage: Uncategorized
Uncategorized Operation 83
Before
29010
After
41013
remove /protocolSection/contactsLocationsModule/locations/11/contacts
Triage: Uncategorized
Uncategorized Operation 84
Before
[
  {
    "name": "Emilio Alba Conejo, MD, PhD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/11/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 85
Before
36.72016
After
37.38283
replace /protocolSection/contactsLocationsModule/locations/11/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 86
Before
-4.42034
After
-5.97317
replace /protocolSection/contactsLocationsModule/locations/12/facility
Triage: Uncategorized
Uncategorized Operation 87
Before
Hospital Universitario Virgen del Rocío
After
Hospital Clínico Universitario de Valencia
remove /protocolSection/contactsLocationsModule/locations/12/status
Triage: Uncategorized
Uncategorized Operation 88
Before
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/12/city
Triage: Uncategorized
Uncategorized Operation 89
Before
Seville
After
Valencia
replace /protocolSection/contactsLocationsModule/locations/12/zip
Triage: Uncategorized
Uncategorized Operation 90
Before
41013
After
46010
remove /protocolSection/contactsLocationsModule/locations/12/contacts
Triage: Uncategorized
Uncategorized Operation 91
Before
[
  {
    "name": "Manuel Ruiz-Borrego, MD",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/12/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 92
Before
37.38283
After
39.47391
replace /protocolSection/contactsLocationsModule/locations/12/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 93
Before
-5.97317
After
-0.37966
remove /protocolSection/contactsLocationsModule/locations/13
Triage: Uncategorized
Uncategorized Operation 94
Before
{
  "zip": "46010",
  "city": "Valencia",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "Juan Miguel Cejalvo Andújar, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Hospital Clínico Universitario de Valencia",
  "geoPoint": {
    "lat": 39.47391,
    "lon": -0.37966
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2022-06
After
2022-11
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2022-06-17
After
2022-11-17
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2022-06-22
After
2022-11-21
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
Raw JSON Patch
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2022-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2022-11-17"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2022-11-21"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/centralContacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/facility",
    "value": "Seattle Cancer Care Alliance"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/2/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/city",
    "value": "Seattle"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/state",
    "value": "Washington"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/zip",
    "value": "98109"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/geoPoint/lat",
    "value": 47.60621
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/geoPoint/lon",
    "value": -122.33207
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/facility",
    "value": "Tom Baker Cancer Centre"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/3/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/city",
    "value": "Calgary"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/state",
    "value": "Alberta"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/zip",
    "value": "T2N4N2"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/country",
    "value": "Canada"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/3/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/geoPoint/lat",
    "value": 51.05011
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/geoPoint/lon",
    "value": -114.08529
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/facility",
    "value": "The Ottawa Hospital Cancer Centre"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/city",
    "value": "Ottawa"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/state",
    "value": "Ontario"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/zip",
    "value": "K1H 8L6"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/geoPoint/lat",
    "value": 45.41117
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/geoPoint/lon",
    "value": -75.69812
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/facility",
    "value": "Sunnybrook Research Institute"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/5/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/city",
    "value": "Toronto"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/zip",
    "value": "M4N3M5"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/5/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/geoPoint/lat",
    "value": 43.70643
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/geoPoint/lon",
    "value": -79.39864
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/facility",
    "value": "Jewish General Hospital"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/city",
    "value": "Montreal"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/state",
    "value": "Quebec"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/zip",
    "value": "H3T1E2"
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  {
    "op": "remove",
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  {
    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/geoPoint/lon",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/facility",
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  },
  {
    "op": "remove",
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  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/city",
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  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/state",
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  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/zip",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/country",
    "value": "Spain"
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  {
    "op": "remove",
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  {
    "op": "replace",
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  {
    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/8/facility",
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  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/8/status"
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/8/city",
    "value": "Barcelona"
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  {
    "op": "remove",
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  {
    "op": "replace",
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  {
    "op": "replace",
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  {
    "op": "replace",
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  {
    "op": "remove",
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  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/city",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/zip",
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  {
    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/facility",
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  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/10/status"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/city",
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  {
    "op": "replace",
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    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/geoPoint/lon",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/11/facility",
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  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/11/status"
  },
  {
    "op": "replace",
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  {
    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/11/geoPoint/lon",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/12/facility",
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  {
    "op": "remove",
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  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/12/city",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/12/zip",
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    "op": "remove",
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  {
    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/12/geoPoint/lon",
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  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/13"
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]