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NCT04224272

A Study of ZW25 (Zanidatamab) With Palbociclib Plus Fulvestrant in Patients With HER2+/HR+ Advanced Breast Cancer

Version 3 to 4 · Jazz Pharmaceuticals

Patch inspector

Version 3 to 4

5 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
design_info_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:05+00
Raw hash
bfab77217c8a01aab9445a463c9e601d77f611d8127591a6491cefebdfb4a0ec
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
add /protocolSection/designModule/designInfo/allocation
Triage: High
Design Change Operation 3
Matched rules
  • design_info_change Design information changes can alter allocation, masking, model, or purpose and need review.
After
NA
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 2 ops
add /protocolSection/contactsLocationsModule/locations/0
Triage: Uncategorized
Uncategorized Operation 4
After
{
  "zip": "90404",
  "city": "Santa Monica",
  "state": "California",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Sara Hurvitz, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "UCLA Hematology/Oncology Parkside",
  "geoPoint": {
    "lat": 34.01949,
    "lon": -118.49138
  }
}
add /protocolSection/contactsLocationsModule/locations/3
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "K1H 8L6",
  "city": "Ottawa",
  "state": "Ontario",
  "status": "RECRUITING",
  "country": "Canada",
  "contacts": [
    {
      "name": "Marie-France Savard, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "The Ottawa Hospital Cancer Centre",
  "geoPoint": {
    "lat": 45.41117,
    "lon": -75.69812
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-08-04
After
2020-08-27
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2020-08-07
After
2020-08-31
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-08-27"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-08-31"
  },
  {
    "op": "add",
    "path": "/protocolSection/designModule/designInfo/allocation",
    "value": "NA"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0",
    "value": {
      "zip": "90404",
      "city": "Santa Monica",
      "state": "California",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Sara Hurvitz, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "UCLA Hematology/Oncology Parkside",
      "geoPoint": {
        "lat": 34.01949,
        "lon": -118.49138
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3",
    "value": {
      "zip": "K1H 8L6",
      "city": "Ottawa",
      "state": "Ontario",
      "status": "RECRUITING",
      "country": "Canada",
      "contacts": [
        {
          "name": "Marie-France Savard, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "The Ottawa Hospital Cancer Centre",
      "geoPoint": {
        "lat": 45.41117,
        "lon": -75.69812
      }
    }
  }
]