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NCT04278144

A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors

Version 24 to 25 · Bolt Biotherapeutics, Inc.

Patch inspector

Version 24 to 25

8 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2025-01-31",
    "old_value": "2023-01-31",
    "delta_days": 731,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2026-10-31",
    "old_value": "2023-07-31",
    "delta_days": 1188,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:08+00
Raw hash
888b63071aaf3de4e9bbeb07c628c0429d2b2585ba042913882c5bc312cf20c9
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2023-01-31
After
2025-01-31
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2023-07-31
After
2026-10-31
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 3 ops
remove /protocolSection/contactsLocationsModule/locations/6
Triage: Uncategorized
Uncategorized Operation 6
Before
{
  "zip": "10032",
  "city": "New York",
  "state": "New York",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "role": "CONTACT",
      "email": "cancerclinicaltrials@cumc.columbia.edu",
      "phone": "212-342-5162"
    }
  ],
  "facility": "Columbia University Medical Center",
  "geoPoint": {
    "lat": 40.71427,
    "lon": -74.00597
  }
}
add /protocolSection/contactsLocationsModule/locations/15
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "08003",
  "city": "Barcelona",
  "state": "Catalonia",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "Laia Cano",
      "role": "CONTACT",
      "email": "lcano@parcdesalutmar.cat",
      "phone": "34 678 165 121",
      "phoneExt": "20090"
    }
  ],
  "facility": "Hospital del Mar",
  "geoPoint": {
    "lat": 41.38879,
    "lon": 2.15899
  }
}
add /protocolSection/contactsLocationsModule/locations/16
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "08035",
  "city": "Barcelona",
  "state": "Catalonia",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "Marta Beltran",
      "role": "CONTACT",
      "email": "mbeltran@vhio.net"
    }
  ],
  "facility": "Hospital Universitario Vall d'Hebron",
  "geoPoint": {
    "lat": 41.38879,
    "lon": 2.15899
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2022-06
After
2023-02
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2022-06-21
After
2023-02-19
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2022-06-23
After
2023-02-21
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2023-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2025-01-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2026-10-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2023-02-19"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2023-02-21"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/15",
    "value": {
      "zip": "08003",
      "city": "Barcelona",
      "state": "Catalonia",
      "status": "RECRUITING",
      "country": "Spain",
      "contacts": [
        {
          "name": "Laia Cano",
          "role": "CONTACT",
          "email": "lcano@parcdesalutmar.cat",
          "phone": "34 678 165 121",
          "phoneExt": "20090"
        }
      ],
      "facility": "Hospital del Mar",
      "geoPoint": {
        "lat": 41.38879,
        "lon": 2.15899
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/16",
    "value": {
      "zip": "08035",
      "city": "Barcelona",
      "state": "Catalonia",
      "status": "RECRUITING",
      "country": "Spain",
      "contacts": [
        {
          "name": "Marta Beltran",
          "role": "CONTACT",
          "email": "mbeltran@vhio.net"
        }
      ],
      "facility": "Hospital Universitario Vall d'Hebron",
      "geoPoint": {
        "lat": 41.38879,
        "lon": 2.15899
      }
    }
  }
]