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NCT04278144

A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors

Phase 1/2 Study of BDC-1001 as a Single Agent and in Combination With Nivolumab in Patients With Advanced HER2-Expressing Solid Tumors

ClinicalTrials.gov
Sponsor
Bolt Biotherapeutics, Inc.
Status
Terminated
Versions
35
Adjacent patches
34
Severity is deterministic, reproducible, uncalibrated triage metadata, not validated review priority or proven wrongdoing. New Evidence Record packages are generated for deterministic event-class membership, not by triage rank alone.

Material event timeline

14 shown
Triage: Low
2020-02-24
Timeline Minor Adjustment
v0 to v1 Pre Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/0/status
/protocolSection/contactsLocationsModule/locations/1/status
/protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Critical
2020-07-24
Primary Outcome Change
v6 to v7 Early Recruitment Inspect patch
/protocolSection/descriptionModule/detailedDescription
/protocolSection/designModule/designInfo/interventionModel
/protocolSection/designModule/designInfo/interventionModelDescription
Triage: High
2021-02-04
Secondary Outcome Change
v11 to v12 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/1
/protocolSection/eligibilityModule/eligibilityCriteria
/protocolSection/outcomesModule/secondaryOutcomes/10/description
Triage: Critical
2021-04-13
Primary Outcome Change
v12 to v13 Early Recruitment Inspect patch
/protocolSection/conditionsModule/conditions/0
/protocolSection/conditionsModule/conditions/1
/protocolSection/conditionsModule/keywords
Triage: High
2021-05-06
Enrollment Change
v15 to v16 Early Recruitment Inspect patch
/protocolSection/designModule/enrollmentInfo/count
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate
Triage: Critical
2021-11-05
Primary Outcome Change
v20 to v21 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/1/interventionNames/1
/protocolSection/armsInterventionsModule/armGroups/1/label
/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/0
Triage: High
2022-01-14
Arm Intervention Change
v22 to v23 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/0/description
/protocolSection/armsInterventionsModule/armGroups/1/description
/protocolSection/contactsLocationsModule/locations/10
Triage: Medium
2023-02-19
Timeline Major Slip
v24 to v25 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/15
/protocolSection/contactsLocationsModule/locations/16
/protocolSection/contactsLocationsModule/locations/6
Triage: Low
2023-08-31
Administrative Contact Change
v25 to v26 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/centralContacts/0/email
/protocolSection/contactsLocationsModule/centralContacts/0/phone
/protocolSection/contactsLocationsModule/locations/16
Triage: Low
2024-05-28
Administrative Contact Change
v28 to v29 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/centralContacts
/protocolSection/contactsLocationsModule/locations/0/contacts
/protocolSection/contactsLocationsModule/locations/0/status
Triage: High
2024-08-16
Enrollment Change
v29 to v30 Late Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/14
/protocolSection/contactsLocationsModule/locations/15
/protocolSection/contactsLocationsModule/locations/20
Triage: High
2025-02-20
Status Termination
v31 to v32 Late Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/19/state
/protocolSection/contactsLocationsModule/locations/20/state
/protocolSection/identificationModule/briefTitle
Triage: Low
2025-09-09
Timeline Actual Date Correction
v32 to v33 Post Recruitment Inspect patch
/protocolSection/identificationModule/briefTitle
/protocolSection/identificationModule/officialTitle
/protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Low
2025-12-10
Results Reconciliation
v33 to v34 Post Recruitment Inspect patch Evidence Record
/annotationSection
/documentSection
/hasResults