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NCT04278144

A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors

Version 25 to 26 · Bolt Biotherapeutics, Inc.

Patch inspector

Version 25 to 26

7 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:08+00
Raw hash
89be750aecfb931c55a905932abef575f6755f7fb971b069f77cd2457d0633f3
Payload
Source URL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 5 ops
replace /protocolSection/contactsLocationsModule/centralContacts/0/phone
Triage: Low
Administrative Contact Change Operation 3
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
1-650-665-9295
After
+1 650 434 8640
replace /protocolSection/contactsLocationsModule/centralContacts/0/email
Triage: Low
Administrative Contact Change Operation 4
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
info@boltbio.com
After
clinicaltrials@boltbio.com
remove /protocolSection/contactsLocationsModule/locations/4
Triage: Uncategorized
Uncategorized Operation 5
Before
{
  "zip": "48202",
  "city": "Detroit",
  "state": "Michigan",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Karie Gignac, RN",
      "role": "CONTACT",
      "email": "Kgignac1@hfhs.org",
      "phone": "313-695-9808"
    }
  ],
  "facility": "Henry Ford Hospital",
  "geoPoint": {
    "lat": 42.33143,
    "lon": -83.04575
  }
}
add /protocolSection/contactsLocationsModule/locations/16
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "28034",
  "city": "Madrid",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "Asier Artazcoz Calvo",
      "role": "CONTACT",
      "email": "artazcozec@gmail.com",
      "phone": "+34 913368263"
    }
  ],
  "facility": "Hospital Universitario Ramón y Cajal",
  "geoPoint": {
    "lat": 40.4165,
    "lon": -3.70256
  }
}
add /protocolSection/contactsLocationsModule/locations/17
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "28041",
  "city": "Madrid",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "Elisa Lorente",
      "role": "CONTACT",
      "email": "Elorente.imas12@h12o.es",
      "phone": "+34 913908922"
    }
  ],
  "facility": "Hospital Universitario 12 de Octubre",
  "geoPoint": {
    "lat": 40.4165,
    "lon": -3.70256
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2023-02-19
After
2023-08-31
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2023-02-21
After
2023-09-05
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2023-08-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2023-09-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/phone",
    "value": "+1 650 434 8640"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/email",
    "value": "clinicaltrials@boltbio.com"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/16",
    "value": {
      "zip": "28034",
      "city": "Madrid",
      "status": "RECRUITING",
      "country": "Spain",
      "contacts": [
        {
          "name": "Asier Artazcoz Calvo",
          "role": "CONTACT",
          "email": "artazcozec@gmail.com",
          "phone": "+34 913368263"
        }
      ],
      "facility": "Hospital Universitario Ramón y Cajal",
      "geoPoint": {
        "lat": 40.4165,
        "lon": -3.70256
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/17",
    "value": {
      "zip": "28041",
      "city": "Madrid",
      "status": "RECRUITING",
      "country": "Spain",
      "contacts": [
        {
          "name": "Elisa Lorente",
          "role": "CONTACT",
          "email": "Elorente.imas12@h12o.es",
          "phone": "+34 913908922"
        }
      ],
      "facility": "Hospital Universitario 12 de Octubre",
      "geoPoint": {
        "lat": 40.4165,
        "lon": -3.70256
      }
    }
  }
]