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NCT04482309

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

Version 0 to 1 · AstraZeneca

Patch inspector

Version 0 to 1

17 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_actualized_earlier",
    "category": "timeline_actualized_earlier",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2020-08-18",
    "old_value": "2020-08-24",
    "delta_days": 6,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "signal": "milestone_realized",
    "category": "milestone_realized",
    "new_date": "2020-08-18",
    "new_type": "ACTUAL",
    "old_date": "2020-08-24",
    "old_type": "ESTIMATED",
    "severity": "low",
    "delta_days": 6,
    "date_struct": "startDateStruct"
  },
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2023-03-20",
    "old_value": "2023-03-24",
    "delta_days": 4,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2023-03-20",
    "old_value": "2023-03-24",
    "delta_days": 4,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:00:17+00
Raw hash
e8fc396866bfb286253832d88df326a5ab193dce60264a44a1bcdcd14d1752e0
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 4 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2020-08-24
After
2020-08-18
replace /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 5
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2023-03-24
After
2023-03-20
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 6
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2023-03-24
After
2023-03-20
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 9 ops
add /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 9
After
NOT_YET_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1/city
Triage: Uncategorized
Uncategorized Operation 10
Before
Taipei
After
Seoul
replace /protocolSection/contactsLocationsModule/locations/1/zip
Triage: Uncategorized
Uncategorized Operation 11
Before
11217
After
03080
replace /protocolSection/contactsLocationsModule/locations/1/country
Triage: Uncategorized
Uncategorized Operation 12
Before
Taiwan
After
South Korea
replace /protocolSection/contactsLocationsModule/locations/1/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 13
Before
25.05306
After
37.566
replace /protocolSection/contactsLocationsModule/locations/1/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 14
Before
121.52639
After
126.9784
add /protocolSection/contactsLocationsModule/locations/1/status
Triage: Uncategorized
Uncategorized Operation 15
After
NOT_YET_RECRUITING
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "zip": "03722",
  "city": "Seoul",
  "status": "NOT_YET_RECRUITING",
  "country": "South Korea",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 37.566,
    "lon": 126.9784
  }
}
add /protocolSection/contactsLocationsModule/locations/3
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "11217",
  "city": "Taipei",
  "status": "RECRUITING",
  "country": "Taiwan",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 25.05306,
    "lon": 121.52639
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-07
After
2020-09
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 7
Before
2020-07-20
After
2020-09-09
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 8
Before
2020-07-22
After
2020-09-14
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
NOT_YET_RECRUITING
After
RECRUITING
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2020-08-18"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2023-03-20"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2023-03-20"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-09-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-09-14"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status",
    "value": "NOT_YET_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/city",
    "value": "Seoul"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/zip",
    "value": "03080"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/country",
    "value": "South Korea"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/geoPoint/lat",
    "value": 37.566
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/geoPoint/lon",
    "value": 126.9784
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1/status",
    "value": "NOT_YET_RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "zip": "03722",
      "city": "Seoul",
      "status": "NOT_YET_RECRUITING",
      "country": "South Korea",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 37.566,
        "lon": 126.9784
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3",
    "value": {
      "zip": "11217",
      "city": "Taipei",
      "status": "RECRUITING",
      "country": "Taiwan",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 25.05306,
        "lon": 121.52639
      }
    }
  }
]