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NCT04482309

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

Version 19 to 20 · AstraZeneca

Patch inspector

Version 19 to 20

13 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2023-05-31",
    "old_value": "2023-03-20",
    "delta_days": 72,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2023-05-31",
    "old_value": "2023-03-20",
    "delta_days": 72,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:00:22+00
Raw hash
fb00454cac80ce1ada64547c7e68667ac6d99e3840c2b1b36b25e85f32cd8bfe
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2023-03-20
After
2023-05-31
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2023-03-20
After
2023-05-31
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 8 ops
add /protocolSection/contactsLocationsModule/locations/49
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "T6G 1Z2",
  "city": "Edmonton",
  "state": "Alberta",
  "status": "WITHDRAWN",
  "country": "Canada",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 53.55014,
    "lon": -113.46871
  }
}
replace /protocolSection/contactsLocationsModule/locations/88/status
Triage: Uncategorized
Uncategorized Operation 7
Before
RECRUITING
After
SUSPENDED
replace /protocolSection/contactsLocationsModule/locations/92/status
Triage: Uncategorized
Uncategorized Operation 8
Before
RECRUITING
After
SUSPENDED
replace /protocolSection/contactsLocationsModule/locations/94/status
Triage: Uncategorized
Uncategorized Operation 9
Before
RECRUITING
After
SUSPENDED
replace /protocolSection/contactsLocationsModule/locations/95/status
Triage: Uncategorized
Uncategorized Operation 10
Before
RECRUITING
After
SUSPENDED
replace /protocolSection/contactsLocationsModule/locations/97/status
Triage: Uncategorized
Uncategorized Operation 11
Before
RECRUITING
After
SUSPENDED
replace /protocolSection/contactsLocationsModule/locations/98/status
Triage: Uncategorized
Uncategorized Operation 12
Before
RECRUITING
After
SUSPENDED
replace /protocolSection/contactsLocationsModule/locations/105/status
Triage: Uncategorized
Uncategorized Operation 13
Before
RECRUITING
After
SUSPENDED
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2022-03
After
2022-04
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2022-03-10
After
2022-04-14
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2022-03-11
After
2022-04-15
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2022-04"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2023-05-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2023-05-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2022-04-14"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2022-04-15"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/49",
    "value": {
      "zip": "T6G 1Z2",
      "city": "Edmonton",
      "state": "Alberta",
      "status": "WITHDRAWN",
      "country": "Canada",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 53.55014,
        "lon": -113.46871
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/88/status",
    "value": "SUSPENDED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/92/status",
    "value": "SUSPENDED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/94/status",
    "value": "SUSPENDED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/95/status",
    "value": "SUSPENDED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/97/status",
    "value": "SUSPENDED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/98/status",
    "value": "SUSPENDED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/105/status",
    "value": "SUSPENDED"
  }
]