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NCT05593094

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

Version 2 to 3 · Hoffmann-La Roche

Patch inspector

Version 2 to 3

23 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:59:54+00
Raw hash
ac5f1147095a5288e6827fb77673acb8cda72d243ad077bd338a66d6870978d1
Payload
Source URL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 21 ops
replace /protocolSection/contactsLocationsModule/centralContacts/0/name
Triage: Low
Administrative Contact Change Operation 3
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
Anders Carey K, MD
After
JoAnna Gontarz, MD
replace /protocolSection/contactsLocationsModule/centralContacts/0/phone
Triage: Low
Administrative Contact Change Operation 4
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
l (919) 684-0313
After
(919) 684-6342
replace /protocolSection/contactsLocationsModule/centralContacts/0/email
Triage: Low
Administrative Contact Change Operation 5
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
carey.anders@duke.edu
After
joanna.gontarz@duke.edu
replace /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 6
Before
RECRUITING
After
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/0/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 7
Before
520-290-2510
remove /protocolSection/contactsLocationsModule/locations/0/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 8
Before
mmodiano@acrcresearch.com
replace /protocolSection/contactsLocationsModule/locations/1/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 9
Before
Arati Chand, MD
After
Leslie Posadas, MD
replace /protocolSection/contactsLocationsModule/locations/1/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 10
Before
achand@airesearch.us
After
leslieposadas@theoncologyinstitute.com
replace /protocolSection/contactsLocationsModule/locations/2/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 11
Before
Nancy Lin, MD
After
Olivia Postel, MD
replace /protocolSection/contactsLocationsModule/locations/2/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 12
Before
617-632-2335
After
877-338-7425
replace /protocolSection/contactsLocationsModule/locations/2/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 13
Before
Nancy_Lin@dfci.harvard.edu
After
OliviaG_Postel@DFCI.HARVARD.EDU
replace /protocolSection/contactsLocationsModule/locations/3/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 14
Before
Aki Morikawa, MD
After
Caner AnswerLine, MD
replace /protocolSection/contactsLocationsModule/locations/3/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 15
Before
734-936-0453
After
800-865-1125
replace /protocolSection/contactsLocationsModule/locations/3/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 16
Before
morikawa@med.umich.edu
After
CancerAnswerLine@med.umich.edu
replace /protocolSection/contactsLocationsModule/locations/4/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 17
Before
assadh@karmanos.org
After
Assadh@karmanos.org
replace /protocolSection/contactsLocationsModule/locations/5/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 18
Before
Anders Carey K, MD
After
JoAnna Gontarz, MD
replace /protocolSection/contactsLocationsModule/locations/5/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 19
Before
919-684-0313
After
919-684-6342
replace /protocolSection/contactsLocationsModule/locations/5/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 20
Before
carey.anders@duke.edu
After
joanna.gontarz@duke.edu
replace /protocolSection/contactsLocationsModule/locations/6/status
Triage: Uncategorized
Uncategorized Operation 21
Before
RECRUITING
After
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/6/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 22
Before
713-792-2923
remove /protocolSection/contactsLocationsModule/locations/6/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 23
Before
RMurthy1@mdanderson.org
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2022-10-28
After
2022-11-03
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2022-10-31
After
2022-11-07
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2022-11-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2022-11-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/name",
    "value": "JoAnna Gontarz, MD"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/phone",
    "value": "(919) 684-6342"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/email",
    "value": "joanna.gontarz@duke.edu"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status",
    "value": "NOT_YET_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/0/phone"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/0/email"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/contacts/0/name",
    "value": "Leslie Posadas, MD"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/contacts/0/email",
    "value": "leslieposadas@theoncologyinstitute.com"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/contacts/0/name",
    "value": "Olivia Postel, MD"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/contacts/0/phone",
    "value": "877-338-7425"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/contacts/0/email",
    "value": "OliviaG_Postel@DFCI.HARVARD.EDU"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/contacts/0/name",
    "value": "Caner AnswerLine, MD"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/contacts/0/phone",
    "value": "800-865-1125"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/contacts/0/email",
    "value": "CancerAnswerLine@med.umich.edu"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/contacts/0/email",
    "value": "Assadh@karmanos.org"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/contacts/0/name",
    "value": "JoAnna Gontarz, MD"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/contacts/0/phone",
    "value": "919-684-6342"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/contacts/0/email",
    "value": "joanna.gontarz@duke.edu"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/status",
    "value": "NOT_YET_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6/contacts/0/phone"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6/contacts/0/email"
  }
]