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NCT05593094

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

A Phase 1 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Efficacy of ZN-A-1041 Enteric Capsules as a Single Agent or in Combination in Patients With HER2-Positive Advanced Solid Tumors

ClinicalTrials.gov
Sponsor
Hoffmann-La Roche
Status
Active Not Recruiting
Versions
12
Adjacent patches
11
Severity is deterministic, reproducible, uncalibrated triage metadata, not validated review priority or proven wrongdoing. New Evidence Record packages are generated for deterministic event-class membership, not by triage rank alone.

Material event timeline

10 shown
Triage: High
2022-10-28
Arm Intervention Change
v1 to v2 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/10/description
/protocolSection/armsInterventionsModule/armGroups/10/interventionNames/0
/protocolSection/armsInterventionsModule/armGroups/10/label
Triage: Low
2022-11-03
Administrative Contact Change
v2 to v3 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/centralContacts/0/email
/protocolSection/contactsLocationsModule/centralContacts/0/name
/protocolSection/contactsLocationsModule/centralContacts/0/phone
Triage: High
2022-11-16
Arm Intervention Change
v3 to v4 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/12/label
/protocolSection/armsInterventionsModule/interventions/12/armGroupLabels/0
/protocolSection/contactsLocationsModule/centralContacts/0/email
Triage: Medium
2023-07-26
Timeline Significant Shift
v4 to v5 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/6/status
/protocolSection/statusModule/completionDateStruct/date
/protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: High
2024-08-27
Secondary Outcome Change
v5 to v6 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/1
/protocolSection/contactsLocationsModule/locations/10
/protocolSection/contactsLocationsModule/locations/11
Triage: High
2024-08-29
Eligibility Change
v6 to v7 Early Recruitment Inspect patch
/protocolSection/eligibilityModule/eligibilityCriteria
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate
Triage: Critical
2025-08-28
Primary Outcome Change
v7 to v8 Early Recruitment Inspect patch
/protocolSection/armsInterventionsModule/armGroups/0/description
/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0
/protocolSection/armsInterventionsModule/armGroups/0/label
Triage: Medium
2025-11-25
Timeline Significant Shift
v8 to v9 Late Recruitment Inspect patch
/protocolSection/statusModule/completionDateStruct/date
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate
Triage: Medium
2026-02-23
Timeline Significant Shift
v9 to v10 Late Recruitment Inspect patch
/protocolSection/statusModule/completionDateStruct/date
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate
Triage: Medium
2026-05-22
Timeline Shift
v10 to v11 Late Recruitment Inspect patch
/protocolSection/statusModule/completionDateStruct/date
/protocolSection/statusModule/lastUpdatePostDateStruct/date
/protocolSection/statusModule/lastUpdateSubmitDate