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NCT05593094

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

Version 3 to 4 · Hoffmann-La Roche

Patch inspector

Version 3 to 4

18 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_changecontact_admin_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:59:54+00
Raw hash
43e8291f0eadf3cb81c51c2eac1829621be72d16c0db3e77b3bf8ecd72e4c395
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 2 ops
replace /protocolSection/armsInterventionsModule/armGroups/12/label
Triage: High
Arm Intervention Change Operation 3
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
1c: ZN-A-1041 + Herceptin plus Perjeta/PHESCO
After
1c: ZN-A-1041 + Herceptin plus Perjeta/PHESGO
replace /protocolSection/armsInterventionsModule/interventions/12/armGroupLabels/0
Triage: High
Arm Intervention Change Operation 4
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
1c: ZN-A-1041 + Herceptin plus Perjeta/PHESCO
After
1c: ZN-A-1041 + Herceptin plus Perjeta/PHESGO
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 14 ops
replace /protocolSection/contactsLocationsModule/centralContacts/0/name
Triage: Low
Administrative Contact Change Operation 5
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
JoAnna Gontarz, MD
After
Ding Zhou, Ph.D
replace /protocolSection/contactsLocationsModule/centralContacts/0/phone
Triage: Low
Administrative Contact Change Operation 6
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
(919) 684-6342
After
(86)-13916360900
replace /protocolSection/contactsLocationsModule/centralContacts/0/email
Triage: Low
Administrative Contact Change Operation 7
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
joanna.gontarz@duke.edu
After
ding.zhou@zionpharma.com
replace /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 8
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/0/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 9
Before
Manuel R Modiano, MD
After
Plezia PharmD
add /protocolSection/contactsLocationsModule/locations/0/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 10
After
520-290-2510
add /protocolSection/contactsLocationsModule/locations/0/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 11
After
pplezia@acrcresearch.com
replace /protocolSection/contactsLocationsModule/locations/1/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 12
Before
Leslie Posadas, MD
After
Leslie Posadas
replace /protocolSection/contactsLocationsModule/locations/2/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 13
Before
Olivia Postel, MD
After
Olivia Postel
replace /protocolSection/contactsLocationsModule/locations/3/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 14
Before
Caner AnswerLine, MD
After
Caner AnswerLine
replace /protocolSection/contactsLocationsModule/locations/5/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 15
Before
JoAnna Gontarz, MD
After
JoAnna Gontarz
add /protocolSection/contactsLocationsModule/locations/5/contacts/1
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "name": "Carey Anders, MD",
  "role": "PRINCIPAL_INVESTIGATOR"
}
add /protocolSection/contactsLocationsModule/locations/6/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 17
After
713-792-2817
add /protocolSection/contactsLocationsModule/locations/6/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 18
After
RMurthy1@mdanderson.org
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2022-11-03
After
2022-11-16
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2022-11-07
After
2022-11-21
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2022-11-16"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2022-11-21"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/12/label",
    "value": "1c: ZN-A-1041 + Herceptin plus Perjeta/PHESGO"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/12/armGroupLabels/0",
    "value": "1c: ZN-A-1041 + Herceptin plus Perjeta/PHESGO"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/name",
    "value": "Ding Zhou, Ph.D"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/phone",
    "value": "(86)-13916360900"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/email",
    "value": "ding.zhou@zionpharma.com"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/0/name",
    "value": "Plezia PharmD"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/0/phone",
    "value": "520-290-2510"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/0/email",
    "value": "pplezia@acrcresearch.com"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/contacts/0/name",
    "value": "Leslie Posadas"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/2/contacts/0/name",
    "value": "Olivia Postel"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/contacts/0/name",
    "value": "Caner AnswerLine"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/contacts/0/name",
    "value": "JoAnna Gontarz"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/5/contacts/1",
    "value": {
      "name": "Carey Anders, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6/contacts/0/phone",
    "value": "713-792-2817"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6/contacts/0/email",
    "value": "RMurthy1@mdanderson.org"
  }
]