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NCT06760637

Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease

AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTICANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE (FOURLIGHT-3)

ClinicalTrials.gov
Sponsor
Pfizer
Status
Active Not Recruiting
Versions
8
Adjacent patches
7
Severity is deterministic, reproducible, uncalibrated triage metadata, not validated review priority or proven wrongdoing. New Evidence Record packages are generated for deterministic event-class membership, not by triage rank alone.

Material event timeline

4 shown
Triage: High
2025-01-14
Secondary Outcome Change
v0 to v1 Pre Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/0/status
/protocolSection/contactsLocationsModule/locations/1/status
/protocolSection/contactsLocationsModule/locations/2/status
Triage: Low
2025-04-24
Timeline Minor Adjustment
v1 to v2 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/0
/protocolSection/contactsLocationsModule/locations/1
/protocolSection/contactsLocationsModule/locations/10
Triage: High
2025-06-17
Secondary Outcome Change
v3 to v4 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/locations/10/facility
/protocolSection/contactsLocationsModule/locations/10/status
/protocolSection/contactsLocationsModule/locations/100
Triage: High
2026-05-18
Enrollment Change
v6 to v7 Early Recruitment Inspect patch
/protocolSection/contactsLocationsModule/centralContacts
/protocolSection/contactsLocationsModule/locations/0/status
/protocolSection/contactsLocationsModule/locations/1/status