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NCT06760637

Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease

Version 1 to 2 · Pfizer

Patch inspector

Version 1 to 2

99 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "later",
    "new_value": "2029-01-02",
    "old_value": "2028-12-30",
    "delta_days": 3,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "later",
    "new_value": "2037-12-29",
    "old_value": "2037-12-26",
    "delta_days": 3,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:13:04+00
Raw hash
b0e6c2ed052abce5be8c23ed2700abd49c88770a8c6f907a755b7764c87dc5aa
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2028-12-30
After
2029-01-02
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2037-12-26
After
2037-12-29
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 94 ops
add /protocolSection/contactsLocationsModule/locations/0
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "85224",
  "city": "Chandler",
  "state": "Arizona",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Ironwood Cancer & Research Centers",
  "geoPoint": {
    "lat": 33.30616,
    "lon": -111.84125
  }
}
add /protocolSection/contactsLocationsModule/locations/1
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "85297",
  "city": "Gilbert",
  "state": "Arizona",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Ironwood Cancer & Research Centers",
  "geoPoint": {
    "lat": 33.35283,
    "lon": -111.78903
  }
}
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "85306",
  "city": "Glendale",
  "state": "Arizona",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Ironwood Cancer & Research Centers",
  "geoPoint": {
    "lat": 33.53865,
    "lon": -112.18599
  }
}
add /protocolSection/contactsLocationsModule/locations/3
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "85202",
  "city": "Mesa",
  "state": "Arizona",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Ironwood Cancer & Research Centers",
  "geoPoint": {
    "lat": 33.42227,
    "lon": -111.82264
  }
}
add /protocolSection/contactsLocationsModule/locations/4
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "85206",
  "city": "Mesa",
  "state": "Arizona",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Ironwood Cancer & Research Centers",
  "geoPoint": {
    "lat": 33.42227,
    "lon": -111.82264
  }
}
add /protocolSection/contactsLocationsModule/locations/5
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "zip": "85028",
  "city": "Phoenix",
  "state": "Arizona",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Ironwood Cancer & Research Centers",
  "geoPoint": {
    "lat": 33.44838,
    "lon": -112.07404
  }
}
add /protocolSection/contactsLocationsModule/locations/6
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "85260",
  "city": "Scottsdale",
  "state": "Arizona",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Ironwood Cancer & Research Centers",
  "geoPoint": {
    "lat": 33.50921,
    "lon": -111.89903
  }
}
add /protocolSection/contactsLocationsModule/locations/7
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "72703",
  "city": "Fayetteville",
  "state": "Arkansas",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Highlands Oncology",
  "geoPoint": {
    "lat": 36.06258,
    "lon": -94.15743
  }
}
add /protocolSection/contactsLocationsModule/locations/8
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "72758",
  "city": "Rogers",
  "state": "Arkansas",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Highlands Oncology",
  "geoPoint": {
    "lat": 36.33202,
    "lon": -94.11854
  }
}
add /protocolSection/contactsLocationsModule/locations/9
Triage: Uncategorized
Uncategorized Operation 15
After
{
  "zip": "72762",
  "city": "Springdale",
  "state": "Arkansas",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Highlands Oncology Group",
  "geoPoint": {
    "lat": 36.18674,
    "lon": -94.12881
  }
}
add /protocolSection/contactsLocationsModule/locations/10
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "zip": "20010",
  "city": "Washington D.C.",
  "state": "District of Columbia",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "MedStar Washington Hospital Center",
  "geoPoint": {
    "lat": 38.89511,
    "lon": -77.03637
  }
}
add /protocolSection/contactsLocationsModule/locations/11
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "32701",
  "city": "Altamonte Springs",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "AdventHealth Altamonte Infusion Center",
  "geoPoint": {
    "lat": 28.66111,
    "lon": -81.36562
  }
}
add /protocolSection/contactsLocationsModule/locations/12
Triage: Uncategorized
Uncategorized Operation 18
After
{
  "zip": "32701",
  "city": "Altamonte Springs",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "AdventHealth Altamonte Springs",
  "geoPoint": {
    "lat": 28.66111,
    "lon": -81.36562
  }
}
add /protocolSection/contactsLocationsModule/locations/13
Triage: Uncategorized
Uncategorized Operation 19
After
{
  "zip": "32701",
  "city": "Altamonte Springs",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "AdventHealth Medical Group Altamonte",
  "geoPoint": {
    "lat": 28.66111,
    "lon": -81.36562
  }
}
add /protocolSection/contactsLocationsModule/locations/14
Triage: Uncategorized
Uncategorized Operation 20
After
{
  "zip": "33180",
  "city": "Aventura",
  "state": "Florida",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Mount Sinai Medical Center, Aventura",
  "geoPoint": {
    "lat": 25.95648,
    "lon": -80.13921
  }
}
add /protocolSection/contactsLocationsModule/locations/15
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "33140",
  "city": "Miami Beach",
  "state": "Florida",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Mount Sinai Comprehensive Cancer Center",
  "geoPoint": {
    "lat": 25.79065,
    "lon": -80.13005
  }
}
add /protocolSection/contactsLocationsModule/locations/16
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "zip": "33140",
  "city": "Miami Beach",
  "state": "Florida",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Mount Sinai Medical Center",
  "geoPoint": {
    "lat": 25.79065,
    "lon": -80.13005
  }
}
add /protocolSection/contactsLocationsModule/locations/17
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "zip": "32763",
  "city": "Orange City",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Mid Florida Hematology and Oncology Center",
  "geoPoint": {
    "lat": 28.94888,
    "lon": -81.29867
  }
}
add /protocolSection/contactsLocationsModule/locations/18
Triage: Uncategorized
Uncategorized Operation 24
After
{
  "zip": "32803",
  "city": "Orlando",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "AdventHealth Orlando",
  "geoPoint": {
    "lat": 28.53834,
    "lon": -81.37924
  }
}
add /protocolSection/contactsLocationsModule/locations/19
Triage: Uncategorized
Uncategorized Operation 25
After
{
  "zip": "32804",
  "city": "Orlando",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "AdventHealth Medical Group Orlando",
  "geoPoint": {
    "lat": 28.53834,
    "lon": -81.37924
  }
}
add /protocolSection/contactsLocationsModule/locations/20
Triage: Uncategorized
Uncategorized Operation 26
After
{
  "zip": "32804",
  "city": "Orlando",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "AdventHealth Orlando Infusion Center",
  "geoPoint": {
    "lat": 28.53834,
    "lon": -81.37924
  }
}
add /protocolSection/contactsLocationsModule/locations/22
Triage: Uncategorized
Uncategorized Operation 27
After
{
  "zip": "60126",
  "city": "Elmhurst",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Endeavor Health",
  "geoPoint": {
    "lat": 41.89947,
    "lon": -87.94034
  }
}
add /protocolSection/contactsLocationsModule/locations/24
Triage: Uncategorized
Uncategorized Operation 28
After
{
  "zip": "60540",
  "city": "Naperville",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Endeavor Health",
  "geoPoint": {
    "lat": 41.78586,
    "lon": -88.14729
  }
}
add /protocolSection/contactsLocationsModule/locations/27
Triage: Uncategorized
Uncategorized Operation 29
After
{
  "zip": "21401",
  "city": "Annapolis",
  "state": "Maryland",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "Velocity Clinical Research",
  "geoPoint": {
    "lat": 38.97859,
    "lon": -76.49184
  }
}
replace /protocolSection/contactsLocationsModule/locations/30/facility
Triage: Uncategorized
Uncategorized Operation 30
Before
Osaka University Hospital
After
Renown Health
replace /protocolSection/contactsLocationsModule/locations/30/status
Triage: Uncategorized
Uncategorized Operation 31
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/30/city
Triage: Uncategorized
Uncategorized Operation 32
Before
Suita
After
Reno
replace /protocolSection/contactsLocationsModule/locations/30/state
Triage: Uncategorized
Uncategorized Operation 33
Before
Osaka
After
Nevada
replace /protocolSection/contactsLocationsModule/locations/30/zip
Triage: Uncategorized
Uncategorized Operation 34
Before
565-0871
After
89502
replace /protocolSection/contactsLocationsModule/locations/30/country
Triage: Uncategorized
Uncategorized Operation 35
Before
Japan
After
United States
replace /protocolSection/contactsLocationsModule/locations/30/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 36
Before
34.76143
After
39.52963
replace /protocolSection/contactsLocationsModule/locations/30/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 37
Before
135.51567
After
-119.8138
replace /protocolSection/contactsLocationsModule/locations/31/facility
Triage: Uncategorized
Uncategorized Operation 38
Before
Kumamoto Shinto General Hospital
After
Renown Regional Medical Center
replace /protocolSection/contactsLocationsModule/locations/31/status
Triage: Uncategorized
Uncategorized Operation 39
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/31/city
Triage: Uncategorized
Uncategorized Operation 40
Before
Kumamoto
After
Reno
replace /protocolSection/contactsLocationsModule/locations/31/zip
Triage: Uncategorized
Uncategorized Operation 41
Before
862-8655
After
89502
replace /protocolSection/contactsLocationsModule/locations/31/country
Triage: Uncategorized
Uncategorized Operation 42
Before
Japan
After
United States
replace /protocolSection/contactsLocationsModule/locations/31/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 43
Before
32.80589
After
39.52963
replace /protocolSection/contactsLocationsModule/locations/31/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 44
Before
130.69181
After
-119.8138
add /protocolSection/contactsLocationsModule/locations/31/state
Triage: Uncategorized
Uncategorized Operation 45
After
Nevada
add /protocolSection/contactsLocationsModule/locations/32
Triage: Uncategorized
Uncategorized Operation 46
After
{
  "zip": "97213",
  "city": "Portland",
  "state": "Oregon",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Providence Cancer Institute Franz Clinic",
  "geoPoint": {
    "lat": 45.52345,
    "lon": -122.67621
  }
}
add /protocolSection/contactsLocationsModule/locations/33
Triage: Uncategorized
Uncategorized Operation 47
After
{
  "zip": "97213",
  "city": "Portland",
  "state": "Oregon",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Providence Portland Medical Center Investigational Drug Services",
  "geoPoint": {
    "lat": 45.52345,
    "lon": -122.67621
  }
}
add /protocolSection/contactsLocationsModule/locations/34
Triage: Uncategorized
Uncategorized Operation 48
After
{
  "zip": "97213",
  "city": "Portland",
  "state": "Oregon",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Providence Portland Medical Center",
  "geoPoint": {
    "lat": 45.52345,
    "lon": -122.67621
  }
}
add /protocolSection/contactsLocationsModule/locations/35
Triage: Uncategorized
Uncategorized Operation 49
After
{
  "zip": "97225",
  "city": "Portland",
  "state": "Oregon",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Providence Investigational Drug Service - Westside",
  "geoPoint": {
    "lat": 45.52345,
    "lon": -122.67621
  }
}
add /protocolSection/contactsLocationsModule/locations/36
Triage: Uncategorized
Uncategorized Operation 50
After
{
  "zip": "97225",
  "city": "Portland",
  "state": "Oregon",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Providence Oncology and Hematology Care Clinic - Westside",
  "geoPoint": {
    "lat": 45.52345,
    "lon": -122.67621
  }
}
add /protocolSection/contactsLocationsModule/locations/37
Triage: Uncategorized
Uncategorized Operation 51
After
{
  "zip": "97225",
  "city": "Portland",
  "state": "Oregon",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "Providence St. Vincent Medical Center",
  "geoPoint": {
    "lat": 45.52345,
    "lon": -122.67621
  }
}
add /protocolSection/contactsLocationsModule/locations/38
Triage: Uncategorized
Uncategorized Operation 52
After
{
  "zip": "75701",
  "city": "Tyler",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center",
  "geoPoint": {
    "lat": 32.35126,
    "lon": -95.30106
  }
}
add /protocolSection/contactsLocationsModule/locations/39
Triage: Uncategorized
Uncategorized Operation 53
After
{
  "zip": "75708",
  "city": "Tyler",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "facility": "The University of Texas Health Science Center at Tyler on behalf of UT Health East Texas HOPE Cancer",
  "geoPoint": {
    "lat": 32.35126,
    "lon": -95.30106
  }
}
add /protocolSection/contactsLocationsModule/locations/40
Triage: Uncategorized
Uncategorized Operation 54
After
{
  "zip": "4814",
  "city": "Douglas",
  "state": "Queensland",
  "status": "NOT_YET_RECRUITING",
  "country": "Australia",
  "facility": "Townsville University Hospital",
  "geoPoint": {
    "lat": -19.32394,
    "lon": 146.75234
  }
}
add /protocolSection/contactsLocationsModule/locations/41
Triage: Uncategorized
Uncategorized Operation 55
After
{
  "zip": "3000",
  "city": "Melbourne",
  "state": "Victoria",
  "status": "NOT_YET_RECRUITING",
  "country": "Australia",
  "facility": "Peter MacCallum Cancer Centre",
  "geoPoint": {
    "lat": -37.814,
    "lon": 144.96332
  }
}
add /protocolSection/contactsLocationsModule/locations/42
Triage: Uncategorized
Uncategorized Operation 56
After
{
  "zip": "3052",
  "city": "Parkville",
  "state": "Victoria",
  "status": "NOT_YET_RECRUITING",
  "country": "Australia",
  "facility": "Royal Melbourne Hospital",
  "geoPoint": {
    "lat": -37.78333,
    "lon": 144.95
  }
}
add /protocolSection/contactsLocationsModule/locations/43
Triage: Uncategorized
Uncategorized Operation 57
After
{
  "zip": "E3B 5N5",
  "city": "Fredericton",
  "state": "New Brunswick",
  "status": "NOT_YET_RECRUITING",
  "country": "Canada",
  "facility": "Dr. Everett Chalmers Regional Hospital",
  "geoPoint": {
    "lat": 45.94541,
    "lon": -66.66558
  }
}
add /protocolSection/contactsLocationsModule/locations/44
Triage: Uncategorized
Uncategorized Operation 58
After
{
  "zip": "100021",
  "city": "Beijing",
  "state": "Beijing Municipality",
  "status": "RECRUITING",
  "country": "China",
  "facility": "Cancer Hospital Chinese Academy of Medical Science",
  "geoPoint": {
    "lat": 39.9075,
    "lon": 116.39723
  }
}
add /protocolSection/contactsLocationsModule/locations/45
Triage: Uncategorized
Uncategorized Operation 59
After
{
  "zip": "100142",
  "city": "Beijing",
  "state": "Beijing Municipality",
  "status": "RECRUITING",
  "country": "China",
  "facility": "Beijing Cancer hospital",
  "geoPoint": {
    "lat": 39.9075,
    "lon": 116.39723
  }
}
add /protocolSection/contactsLocationsModule/locations/46
Triage: Uncategorized
Uncategorized Operation 60
After
{
  "zip": "528000",
  "city": "Foshan",
  "state": "Guangdong",
  "status": "NOT_YET_RECRUITING",
  "country": "China",
  "facility": "The First People's Hospital of Foshan",
  "geoPoint": {
    "lat": 23.02677,
    "lon": 113.13148
  }
}
add /protocolSection/contactsLocationsModule/locations/47
Triage: Uncategorized
Uncategorized Operation 61
After
{
  "zip": "510060",
  "city": "Guangzhou",
  "state": "Guangdong",
  "status": "RECRUITING",
  "country": "China",
  "facility": "Sun Yat-sen University Cancer Center",
  "geoPoint": {
    "lat": 23.11667,
    "lon": 113.25
  }
}
add /protocolSection/contactsLocationsModule/locations/48
Triage: Uncategorized
Uncategorized Operation 62
After
{
  "zip": "430030",
  "city": "Wuhan",
  "state": "Hubei",
  "status": "RECRUITING",
  "country": "China",
  "facility": "Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology",
  "geoPoint": {
    "lat": 30.58333,
    "lon": 114.26667
  }
}
add /protocolSection/contactsLocationsModule/locations/49
Triage: Uncategorized
Uncategorized Operation 63
After
{
  "zip": "210031",
  "city": "Nanjing",
  "state": "Jiangsu",
  "status": "NOT_YET_RECRUITING",
  "country": "China",
  "facility": "Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School",
  "geoPoint": {
    "lat": 32.06167,
    "lon": 118.77778
  }
}
add /protocolSection/contactsLocationsModule/locations/50
Triage: Uncategorized
Uncategorized Operation 64
After
{
  "zip": "130021",
  "city": "Changchun",
  "state": "Jilin",
  "status": "RECRUITING",
  "country": "China",
  "facility": "The First Hospital of Jilin University",
  "geoPoint": {
    "lat": 43.88,
    "lon": 125.32278
  }
}
add /protocolSection/contactsLocationsModule/locations/51
Triage: Uncategorized
Uncategorized Operation 65
After
{
  "zip": "116023",
  "city": "Dalian",
  "state": "Liaoning",
  "status": "RECRUITING",
  "country": "China",
  "facility": "The 2nd Affiliated Hospital of Dalian Medical University",
  "geoPoint": {
    "lat": 38.91222,
    "lon": 121.60222
  }
}
add /protocolSection/contactsLocationsModule/locations/52
Triage: Uncategorized
Uncategorized Operation 66
After
{
  "zip": "110015",
  "city": "Shenyang",
  "state": "Liaoning",
  "status": "NOT_YET_RECRUITING",
  "country": "China",
  "facility": "The First Hospital of China Medical University",
  "geoPoint": {
    "lat": 41.79222,
    "lon": 123.43278
  }
}
add /protocolSection/contactsLocationsModule/locations/53
Triage: Uncategorized
Uncategorized Operation 67
After
{
  "zip": "710061",
  "city": "Xi'an",
  "state": "Shaanxi",
  "status": "RECRUITING",
  "country": "China",
  "facility": "The First Affiliated Hospital of Xi'an Jiaotong University",
  "geoPoint": {
    "lat": 34.25833,
    "lon": 108.92861
  }
}
add /protocolSection/contactsLocationsModule/locations/54
Triage: Uncategorized
Uncategorized Operation 68
After
{
  "zip": "310016",
  "city": "Hangzhou",
  "state": "Zhejiang",
  "status": "NOT_YET_RECRUITING",
  "country": "China",
  "facility": "Sir Run Run Shaw Hospital",
  "geoPoint": {
    "lat": 30.29365,
    "lon": 120.16142
  }
}
add /protocolSection/contactsLocationsModule/locations/55
Triage: Uncategorized
Uncategorized Operation 69
After
{
  "zip": "395002",
  "city": "Surat",
  "state": "Gujarat",
  "status": "NOT_YET_RECRUITING",
  "country": "India",
  "facility": "Nirmal Hospital Pvt Ltd.",
  "geoPoint": {
    "lat": 21.19594,
    "lon": 72.83023
  }
}
add /protocolSection/contactsLocationsModule/locations/56
Triage: Uncategorized
Uncategorized Operation 70
After
{
  "zip": "401107",
  "city": "Thane",
  "state": "Maharashtra",
  "status": "NOT_YET_RECRUITING",
  "country": "India",
  "facility": "Bhakti Vedanta Hospital and Research Institute",
  "geoPoint": {
    "lat": 19.19704,
    "lon": 72.96355
  }
}
add /protocolSection/contactsLocationsModule/locations/57
Triage: Uncategorized
Uncategorized Operation 71
After
{
  "zip": "110085",
  "city": "New Delhi",
  "state": "National Capital Territory of Delhi",
  "status": "NOT_YET_RECRUITING",
  "country": "India",
  "facility": "Rajiv Gandhi Cancer Institute And Research Centre",
  "geoPoint": {
    "lat": 28.62137,
    "lon": 77.2148
  }
}
add /protocolSection/contactsLocationsModule/locations/58
Triage: Uncategorized
Uncategorized Operation 72
After
{
  "zip": "9112001",
  "city": "Jerusalem",
  "state": "Jerusalem",
  "status": "NOT_YET_RECRUITING",
  "country": "Israel",
  "facility": "Hadassah Medical Center",
  "geoPoint": {
    "lat": 31.76904,
    "lon": 35.21633
  }
}
add /protocolSection/contactsLocationsModule/locations/59
Triage: Uncategorized
Uncategorized Operation 73
After
{
  "zip": "3109601",
  "city": "Haifa",
  "state": "Northern District",
  "status": "NOT_YET_RECRUITING",
  "country": "Israel",
  "facility": "Rambam Health Care Campus"
}
add /protocolSection/contactsLocationsModule/locations/60
Triage: Uncategorized
Uncategorized Operation 74
After
{
  "zip": "6423906",
  "city": "Tel Aviv",
  "state": "TELL ABĪB",
  "status": "NOT_YET_RECRUITING",
  "country": "Israel",
  "facility": "Sourasky Medical Center",
  "geoPoint": {
    "lat": 32.08088,
    "lon": 34.78057
  }
}
add /protocolSection/contactsLocationsModule/locations/61
Triage: Uncategorized
Uncategorized Operation 75
After
{
  "zip": "466-8560",
  "city": "Nagoya",
  "state": "Aichi-ken",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Nagoya University Hospital",
  "geoPoint": {
    "lat": 35.18147,
    "lon": 136.90641
  }
}
add /protocolSection/contactsLocationsModule/locations/62
Triage: Uncategorized
Uncategorized Operation 76
After
{
  "zip": "467-8602",
  "city": "Nagoya",
  "state": "Aichi-ken",
  "status": "NOT_YET_RECRUITING",
  "country": "Japan",
  "facility": "Nagoya City University Hospital",
  "geoPoint": {
    "lat": 35.18147,
    "lon": 136.90641
  }
}
add /protocolSection/contactsLocationsModule/locations/63
Triage: Uncategorized
Uncategorized Operation 77
After
{
  "zip": "373-8550",
  "city": "Otashi",
  "state": "Gunma",
  "status": "NOT_YET_RECRUITING",
  "country": "Japan",
  "facility": "Gunma Prefectural Cancer Center"
}
add /protocolSection/contactsLocationsModule/locations/64
Triage: Uncategorized
Uncategorized Operation 78
After
{
  "zip": "003-0804",
  "city": "Sapporo",
  "state": "Hokkaido",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "National Hospital Organization Hokkaido Cancer Center",
  "geoPoint": {
    "lat": 43.06667,
    "lon": 141.35
  }
}
add /protocolSection/contactsLocationsModule/locations/65
Triage: Uncategorized
Uncategorized Operation 79
After
{
  "zip": "2418515",
  "city": "Yokohama",
  "state": "Kanagawa",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Kanagawa cancer center",
  "geoPoint": {
    "lat": 35.43333,
    "lon": 139.65
  }
}
add /protocolSection/contactsLocationsModule/locations/66
Triage: Uncategorized
Uncategorized Operation 80
After
{
  "zip": "606-8507",
  "city": "Sakyo-ku",
  "state": "Kyoto",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Kyoto University Hospital"
}
add /protocolSection/contactsLocationsModule/locations/67
Triage: Uncategorized
Uncategorized Operation 81
After
{
  "zip": "980-8574",
  "city": "Sendai",
  "state": "Miyagi",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Tohoku University Hospital",
  "geoPoint": {
    "lat": 38.26667,
    "lon": 140.86667
  }
}
add /protocolSection/contactsLocationsModule/locations/68
Triage: Uncategorized
Uncategorized Operation 82
After
{
  "zip": "565-0871",
  "city": "Suita",
  "state": "Osaka",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Osaka University Hospital",
  "geoPoint": {
    "lat": 34.76143,
    "lon": 135.51567
  }
}
add /protocolSection/contactsLocationsModule/locations/69
Triage: Uncategorized
Uncategorized Operation 83
After
{
  "zip": "113-8431",
  "city": "Bunkyo-ku",
  "state": "Tokyo",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Juntendo University Hospital"
}
add /protocolSection/contactsLocationsModule/locations/70
Triage: Uncategorized
Uncategorized Operation 84
After
{
  "zip": "104-0045",
  "city": "Chuo-ku",
  "state": "Tokyo",
  "status": "NOT_YET_RECRUITING",
  "country": "Japan",
  "facility": "National Cancer Center Hospital"
}
add /protocolSection/contactsLocationsModule/locations/71
Triage: Uncategorized
Uncategorized Operation 85
After
{
  "zip": "135-8550",
  "city": "Koto-ku",
  "state": "Tokyo",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "The Cancer Institute Hospital of JFCR"
}
add /protocolSection/contactsLocationsModule/locations/72
Triage: Uncategorized
Uncategorized Operation 86
After
{
  "zip": "142-8666",
  "city": "Shinagawa",
  "state": "Tokyo",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Showa University Hospital"
}
add /protocolSection/contactsLocationsModule/locations/73
Triage: Uncategorized
Uncategorized Operation 87
After
{
  "zip": "162-8655",
  "city": "Shinjuku-ku",
  "state": "Tokyo",
  "status": "NOT_YET_RECRUITING",
  "country": "Japan",
  "facility": "Center Hospital of the National Center for Global Health and Medicine"
}
add /protocolSection/contactsLocationsModule/locations/74
Triage: Uncategorized
Uncategorized Operation 88
After
{
  "zip": "260-8717",
  "city": "Chiba",
  "status": "NOT_YET_RECRUITING",
  "country": "Japan",
  "facility": "Chiba Cancer Center",
  "geoPoint": {
    "lat": 35.6,
    "lon": 140.11667
  }
}
add /protocolSection/contactsLocationsModule/locations/75
Triage: Uncategorized
Uncategorized Operation 89
After
{
  "zip": "730-8518",
  "city": "Hiroshima",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Hiroshima City Hiroshima Citizens Hospital",
  "geoPoint": {
    "lat": 34.4,
    "lon": 132.45
  }
}
add /protocolSection/contactsLocationsModule/locations/76
Triage: Uncategorized
Uncategorized Operation 90
After
{
  "zip": "862-8655",
  "city": "Kumamoto",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Kumamoto Shinto General Hospital",
  "geoPoint": {
    "lat": 32.80589,
    "lon": 130.69181
  }
}
add /protocolSection/contactsLocationsModule/locations/77
Triage: Uncategorized
Uncategorized Operation 91
After
{
  "zip": "700-8558",
  "city": "Okayama",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Okayama University Hospital",
  "geoPoint": {
    "lat": 34.65,
    "lon": 133.93333
  }
}
add /protocolSection/contactsLocationsModule/locations/78
Triage: Uncategorized
Uncategorized Operation 92
After
{
  "zip": "540-0006",
  "city": "Osaka",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "National Hospital Organization Osaka National Hospital",
  "geoPoint": {
    "lat": 34.69379,
    "lon": 135.50107
  }
}
add /protocolSection/contactsLocationsModule/locations/79
Triage: Uncategorized
Uncategorized Operation 93
After
{
  "zip": "541-8567",
  "city": "Osaka",
  "status": "RECRUITING",
  "country": "Japan",
  "facility": "Osaka International Cancer Institute",
  "geoPoint": {
    "lat": 34.69379,
    "lon": 135.50107
  }
}
add /protocolSection/contactsLocationsModule/locations/80
Triage: Uncategorized
Uncategorized Operation 94
After
{
  "zip": "413 45",
  "city": "Gothenburg",
  "state": "Västra Götalands LÄN [se-14]",
  "status": "NOT_YET_RECRUITING",
  "country": "Sweden",
  "facility": "Sahlgrenska Universitetssjukhuset",
  "geoPoint": {
    "lat": 57.70716,
    "lon": 11.96679
  }
}
add /protocolSection/contactsLocationsModule/locations/81
Triage: Uncategorized
Uncategorized Operation 95
After
{
  "zip": "4600",
  "city": "Olten",
  "status": "NOT_YET_RECRUITING",
  "country": "Switzerland",
  "facility": "Kantonsspital Olten",
  "geoPoint": {
    "lat": 47.34999,
    "lon": 7.90329
  }
}
add /protocolSection/contactsLocationsModule/locations/82
Triage: Uncategorized
Uncategorized Operation 96
After
{
  "zip": "302",
  "city": "Zhubei",
  "state": "Hsinchu",
  "status": "NOT_YET_RECRUITING",
  "country": "Taiwan",
  "facility": "National Taiwan University Hospital - Hsinchu branch",
  "geoPoint": {
    "lat": 24.83833,
    "lon": 121.00778
  }
}
add /protocolSection/contactsLocationsModule/locations/83
Triage: Uncategorized
Uncategorized Operation 97
After
{
  "zip": "10002",
  "city": "Taipei",
  "status": "NOT_YET_RECRUITING",
  "country": "Taiwan",
  "facility": "National Taiwan University Hospital",
  "geoPoint": {
    "lat": 25.05306,
    "lon": 121.52639
  }
}
add /protocolSection/contactsLocationsModule/locations/84
Triage: Uncategorized
Uncategorized Operation 98
After
{
  "zip": "112",
  "city": "Taipei",
  "status": "NOT_YET_RECRUITING",
  "country": "Taiwan",
  "facility": "Koo Foundation Sun Yat-Sen Cancer Center",
  "geoPoint": {
    "lat": 25.05306,
    "lon": 121.52639
  }
}
add /protocolSection/contactsLocationsModule/locations/85
Triage: Uncategorized
Uncategorized Operation 99
After
{
  "zip": "333",
  "city": "Taoyuan",
  "status": "NOT_YET_RECRUITING",
  "country": "Taiwan",
  "facility": "Chang Gung Medical Foundation-Linkou Branch",
  "geoPoint": {
    "lat": 24.99368,
    "lon": 121.29696
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2025-01
After
2025-04
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2025-01-14
After
2025-04-24
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2025-01-16
After
2025-04-25
Raw JSON Patch
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2025-04"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2029-01-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2037-12-29"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2025-04-24"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2025-04-25"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0",
    "value": {
      "zip": "85224",
      "city": "Chandler",
      "state": "Arizona",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Ironwood Cancer & Research Centers",
      "geoPoint": {
        "lat": 33.30616,
        "lon": -111.84125
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1",
    "value": {
      "zip": "85297",
      "city": "Gilbert",
      "state": "Arizona",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Ironwood Cancer & Research Centers",
      "geoPoint": {
        "lat": 33.35283,
        "lon": -111.78903
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "zip": "85306",
      "city": "Glendale",
      "state": "Arizona",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Ironwood Cancer & Research Centers",
      "geoPoint": {
        "lat": 33.53865,
        "lon": -112.18599
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3",
    "value": {
      "zip": "85202",
      "city": "Mesa",
      "state": "Arizona",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Ironwood Cancer & Research Centers",
      "geoPoint": {
        "lat": 33.42227,
        "lon": -111.82264
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/4",
    "value": {
      "zip": "85206",
      "city": "Mesa",
      "state": "Arizona",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Ironwood Cancer & Research Centers",
      "geoPoint": {
        "lat": 33.42227,
        "lon": -111.82264
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/5",
    "value": {
      "zip": "85028",
      "city": "Phoenix",
      "state": "Arizona",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Ironwood Cancer & Research Centers",
      "geoPoint": {
        "lat": 33.44838,
        "lon": -112.07404
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6",
    "value": {
      "zip": "85260",
      "city": "Scottsdale",
      "state": "Arizona",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Ironwood Cancer & Research Centers",
      "geoPoint": {
        "lat": 33.50921,
        "lon": -111.89903
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/7",
    "value": {
      "zip": "72703",
      "city": "Fayetteville",
      "state": "Arkansas",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Highlands Oncology",
      "geoPoint": {
        "lat": 36.06258,
        "lon": -94.15743
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/8",
    "value": {
      "zip": "72758",
      "city": "Rogers",
      "state": "Arkansas",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Highlands Oncology",
      "geoPoint": {
        "lat": 36.33202,
        "lon": -94.11854
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/9",
    "value": {
      "zip": "72762",
      "city": "Springdale",
      "state": "Arkansas",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Highlands Oncology Group",
      "geoPoint": {
        "lat": 36.18674,
        "lon": -94.12881
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/10",
    "value": {
      "zip": "20010",
      "city": "Washington D.C.",
      "state": "District of Columbia",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "MedStar Washington Hospital Center",
      "geoPoint": {
        "lat": 38.89511,
        "lon": -77.03637
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/11",
    "value": {
      "zip": "32701",
      "city": "Altamonte Springs",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "AdventHealth Altamonte Infusion Center",
      "geoPoint": {
        "lat": 28.66111,
        "lon": -81.36562
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/12",
    "value": {
      "zip": "32701",
      "city": "Altamonte Springs",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "AdventHealth Altamonte Springs",
      "geoPoint": {
        "lat": 28.66111,
        "lon": -81.36562
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/13",
    "value": {
      "zip": "32701",
      "city": "Altamonte Springs",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "AdventHealth Medical Group Altamonte",
      "geoPoint": {
        "lat": 28.66111,
        "lon": -81.36562
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/14",
    "value": {
      "zip": "33180",
      "city": "Aventura",
      "state": "Florida",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "Mount Sinai Medical Center, Aventura",
      "geoPoint": {
        "lat": 25.95648,
        "lon": -80.13921
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/15",
    "value": {
      "zip": "33140",
      "city": "Miami Beach",
      "state": "Florida",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "Mount Sinai Comprehensive Cancer Center",
      "geoPoint": {
        "lat": 25.79065,
        "lon": -80.13005
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/16",
    "value": {
      "zip": "33140",
      "city": "Miami Beach",
      "state": "Florida",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "Mount Sinai Medical Center",
      "geoPoint": {
        "lat": 25.79065,
        "lon": -80.13005
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/17",
    "value": {
      "zip": "32763",
      "city": "Orange City",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "Mid Florida Hematology and Oncology Center",
      "geoPoint": {
        "lat": 28.94888,
        "lon": -81.29867
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/18",
    "value": {
      "zip": "32803",
      "city": "Orlando",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "AdventHealth Orlando",
      "geoPoint": {
        "lat": 28.53834,
        "lon": -81.37924
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/19",
    "value": {
      "zip": "32804",
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